Sulfamethoxazole and Proctitis - a phase IV clinical study of FDA data

Summary:

Proctitis is reported as a side effect among people who take Sulfamethoxazole (sulfamethoxazole), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Sodium Bicarbonate, and have Crohn's disease.

The phase IV clinical study analyzes which people have Proctitis when taking Sulfamethoxazole. It is created by eHealthMe based on reports of 13,142 people who have side effects when taking Sulfamethoxazole from the FDA, and is updated regularly.

What is Sulfamethoxazole?

Sulfamethoxazole has active ingredients of sulfamethoxazole. It is often used in urinary tract infection. eHealthMe is studying from 13,360 Sulfamethoxazole users. Check the latest studies of Sulfamethoxazole.

What is Proctitis?

Proctitis (inflammation of the rectum and anus) is found to be associated with 461 drugs and 618 conditions by eHealthMe. Check the latest studies of Proctitis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

13,142 people reported to have side effects when taking Sulfamethoxazole.
Among them, 40 people (0.3%) have Proctitis.

Among these 40 people:

How long have people been on Sulfamethoxazole when they have Proctitis? *

What is the gender of people who have Proctitis when taking Sulfamethoxazole? *

female: 93.33 %
male: 6.67 %

What is the age of people who have Proctitis when taking Sulfamethoxazole? *

What are other drugs people take besides Sulfamethoxazole? *

Sodium Bicarbonate: 38 people, 95.00%
Acetaminophen: 37 people, 92.50%
Prednisone: 37 people, 92.50%
Clarithromycin: 37 people, 92.50%
Potassium Chloride: 37 people, 92.50%
Ertapenem Sodium: 37 people, 92.50%
Calcium Carbonate: 37 people, 92.50%
Pantoprazole: 37 people, 92.50%
Clotrimazole: 37 people, 92.50%
Hydromorphone Hydrochloride: 37 people, 92.50%

What are other side effects people have besides Proctitis? *

Fever: 38 people, 95.00%
Abdominal Pain: 37 people, 92.50%
Headache (pain in head): 37 people, 92.50%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 37 people, 92.50%
Rectal Haemorrhage (bleeding from anus): 37 people, 92.50%
Rashes (redness): 37 people, 92.50%
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly): 37 people, 92.50%
Anaemia (lack of blood): 37 people, 92.50%
Constipation: 37 people, 92.50%
Oral Candidiasis (fungal infection of mouth): 37 people, 92.50%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 33 people, 82.50%
Colitis (inflammation of colon): 23 people, 57.50%
Allergies: 22 people, 55.00%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 14 people, 35.00%
Fever: 14 people, 35.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 9 people, 22.50%
Oral Candidiasis (fungal infection of mouth): 7 people, 17.50%
Nausea (feeling of having an urge to vomit): 6 people, 15.00%
Pain: 5 people, 12.50%
Urethral Disorder: 4 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Sulfamethoxazole and have Proctitis?

- Check whether Proctitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sulfamethoxazole:

Sulfamethoxazole (13,360 reports)

Proctitis treatments and more:

Proctitis (4,383 reports)

Browse all side effects of Sulfamethoxazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Proctitis:

Proctitis (461 drugs)

Browse all the conditions that are associated with Proctitis:

Proctitis (618 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole (the active ingredients of Sulfamethoxazole) and Sulfamethoxazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.