Sulfasalazine and Hyperkeratosis - a phase IV clinical study of FDA data

Summary:

Hyperkeratosis is reported as a side effect among people who take Sulfasalazine (sulfasalazine), especially for people who are female, 60+ old, also take Tylenol, and have Pain.

The phase IV clinical study analyzes which people have Hyperkeratosis when taking Sulfasalazine. It is created by eHealthMe based on reports of 95,646 people who have side effects when taking Sulfasalazine from the FDA, and is updated regularly.

What is Sulfasalazine?

Sulfasalazine has active ingredients of sulfasalazine. It is often used in rheumatoid arthritis. eHealthMe is studying from 96,787 Sulfasalazine users. Check the latest studies of Sulfasalazine.

What is Hyperkeratosis?

Hyperkeratosis (thickening of the outer layer of the skin) is found to be associated with 780 drugs and 771 conditions by eHealthMe. Check the latest studies of Hyperkeratosis.

On Jul, 16, 2026

95,646 people reported to have side effects when taking Sulfasalazine.
Among them, 31 people (0.03%) have Hyperkeratosis.

Could Sulfasalazine cause Hyperkeratosis?

Among these 31 people:

What is the gender of people who have Hyperkeratosis when taking Sulfasalazine? *

female: 51.72 %
male: 48.28 %

What is the age of people who have Hyperkeratosis when taking Sulfasalazine? *

What are other drugs people take besides Sulfasalazine? *

What are other side effects people have besides Hyperkeratosis? *

Joint Pain: 18 people, 58.06%
Pain: 18 people, 58.06%
Pain In Extremity: 17 people, 54.84%
High Blood Pressure: 14 people, 45.16%
Cough: 12 people, 38.71%
Rashes (redness): 12 people, 38.71%
Nasopharyngitis (inflammation of the nasopharynx): 11 people, 35.48%
Infusion Related Reaction: 11 people, 35.48%
Oxygen Saturation Decreased: 11 people, 35.48%
Blood Pressure Fluctuation: 11 people, 35.48%

What are the existing conditions these people have? *

Pain: 6 people, 19.35%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 16.13%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 6.45%
Dyslipidaemia (abnormal amount of lipids): 2 people, 6.45%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 2 people, 6.45%
Nuclear Magnetic Resonance Imaging Brain: 2 people, 6.45%
Hepatic Neoplasm Malignant (liver cancer): 2 people, 6.45%
Itching: 2 people, 6.45%
High Blood Cholesterol: 1 person, 3.23%
Diabetes: 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Sulfasalazine and have Hyperkeratosis?

- Check whether Hyperkeratosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sulfasalazine:

Sulfasalazine (96,787 reports)

Hyperkeratosis treatments and more:

Hyperkeratosis (8,056 reports)

Browse all side effects of Sulfasalazine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkeratosis:

Hyperkeratosis (780 drugs)

Browse all the conditions that are associated with Hyperkeratosis:

Hyperkeratosis (771 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfasalazine (the active ingredients of Sulfasalazine) and Sulfasalazine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.