Sumatriptan and Adrenal insufficiency - a phase IV clinical study of FDA data

Summary:

Adrenal insufficiency is reported as a side effect among people who take Sumatriptan (sumatriptan succinate), especially for people who are female, 20-29 old, also take Omeprazole, and have Abdominal pain.

The phase IV clinical study analyzes which people have Adrenal insufficiency when taking Sumatriptan. It is created by eHealthMe based on reports of 17,179 people who have side effects when taking Sumatriptan from the FDA, and is updated regularly.

What is Sumatriptan?

Sumatriptan has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 18,159 Sumatriptan users. Check the latest studies of Sumatriptan.

What is Adrenal insufficiency?

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids) is found to be associated with 965 drugs and 1,094 conditions by eHealthMe. Check the latest studies of Adrenal insufficiency.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

17,179 people reported to have side effects when taking Sumatriptan.
Among them, 48 people (0.28%) have Adrenal insufficiency.

Could Sumatriptan cause Adrenal insufficiency?

Among these 48 people:

What is the gender of people who have Adrenal insufficiency when taking Sumatriptan? *

female: 97.67 %
male: 2.33 %

What is the age of people who have Adrenal insufficiency when taking Sumatriptan? *

What are other drugs people take besides Sumatriptan? *

Omeprazole: 42 people, 87.50%
Ibuprofen: 41 people, 85.42%
Metoclopramide: 40 people, 83.33%
Hydrocortisone: 32 people, 66.67%
Gabapentin: 32 people, 66.67%
Lansoprazole: 30 people, 62.50%
Pregabalin: 30 people, 62.50%
Tramadol: 23 people, 47.92%
Tramadol Hydrochloride: 17 people, 35.42%
Acetaminophen: 14 people, 29.17%

What are other side effects people have besides Adrenal insufficiency? *

Hyperprolactinaemia (abnormally high levels of prolactin in the blood): 35 people, 72.92%
Pituitary Tumor Benign: 34 people, 70.83%
Vision Blurred: 33 people, 68.75%
Fatigue (feeling of tiredness): 32 people, 66.67%
Nausea And Vomiting: 32 people, 66.67%
Headache (pain in head): 32 people, 66.67%
Abdominal Pain: 31 people, 64.58%
Dizziness: 31 people, 64.58%
Secondary Adrenocortical Insufficiency (inadequate secretion of acth by the pituitary gland): 30 people, 62.50%
Drug Ineffective: 9 people, 18.75%

What are the existing conditions these people have? *

Abdominal Pain: 43 people, 89.58%
Nausea (feeling of having an urge to vomit): 31 people, 64.58%
Indigestion: 29 people, 60.42%
Nausea And Vomiting: 28 people, 58.33%
Primary Immunodeficiency Syndrome: 2 people, 4.17%
Pain: 2 people, 4.17%
Immunodeficiency Common Variable: 2 people, 4.17%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 2.08%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 1 person, 2.08%
Autoimmune Disorder (a condition in which the immune system attacks the body's normal substances and tissue): 1 person, 2.08%

* Approximation only. Some reports may have incomplete information.

Do you take Sumatriptan and have Adrenal insufficiency?

- Check whether Adrenal insufficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sumatriptan:

Sumatriptan (18,159 reports)

Browse all side effects of Sumatriptan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Adrenal insufficiency:

Adrenal insufficiency (965 drugs)

Browse all the conditions that are associated with Adrenal insufficiency:

Adrenal insufficiency (1,094 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sumatriptan succinate (the active ingredients of Sumatriptan) and Sumatriptan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.