Symmetrel and Hyperkinesia - a phase IV clinical study of FDA data

Summary:

Hyperkinesia is reported as a side effect among people who take Symmetrel (amantadine hydrochloride), especially for people who are male, 60+ old, also take Sinemet, and have Abnormal faeces.

The phase IV clinical study analyzes which people have Hyperkinesia when taking Symmetrel. It is created by eHealthMe based on reports of 3,370 people who have side effects when taking Symmetrel from the FDA, and is updated regularly.

What is Symmetrel?

Symmetrel has active ingredients of amantadine hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 3,398 Symmetrel users. Check the latest studies of Symmetrel.

What is Hyperkinesia?

Hyperkinesia (higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs) is found to be associated with 204 drugs and 316 conditions by eHealthMe. Check the latest studies of Hyperkinesia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

3,370 people reported to have side effects when taking Symmetrel.
Among them, 96 people (2.85%) have Hyperkinesia.

Among these 96 people:

What is the gender of people who have Hyperkinesia when taking Symmetrel? *

female: 48.96 %
male: 51.04 %

What is the age of people who have Hyperkinesia when taking Symmetrel? *

What are other drugs people take besides Symmetrel? *

What are other side effects people have besides Hyperkinesia? *

On And Off Phenomenon: 78 people, 81.25%
Dyskinesia (abnormality or impairment of voluntary movement): 77 people, 80.21%
Muscle Rigidity (muscle stiffness): 55 people, 57.29%
Weight Decreased: 52 people, 54.17%
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases): 52 people, 54.17%
Gait Disturbance: 51 people, 53.12%
Mobility Decreased (ability to move is reduced): 50 people, 52.08%
Freezing Phenomenon: 46 people, 47.92%
Fatigue (feeling of tiredness): 45 people, 46.88%
Tremor (trembling or shaking movements in one or more parts of your body): 42 people, 43.75%

What are the existing conditions these people have? *

Abnormal Faeces (abnormal stool): 36 people, 37.50%
Constipation: 20 people, 20.83%
Hallucinations (sensations that appear real but are created by your mind): 10 people, 10.42%
Migraine (headache): 6 people, 6.25%
Dyskinesia (abnormality or impairment of voluntary movement): 6 people, 6.25%
Muscle Spasms (muscle contraction): 2 people, 2.08%
Muscle Rigidity (muscle stiffness): 2 people, 2.08%
Depression: 2 people, 2.08%
Prostatic Disorder: 1 person, 1.04%
Pain: 1 person, 1.04%

* Approximation only. Some reports may have incomplete information.

Do you take Symmetrel and have Hyperkinesia?

- Check whether Hyperkinesia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Symmetrel:

Symmetrel (3,398 reports)

Hyperkinesia treatments and more:

Hyperkinesia (2,748 reports)

Browse all side effects of Symmetrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkinesia:

Hyperkinesia (204 drugs)

Browse all the conditions that are associated with Hyperkinesia:

Hyperkinesia (316 conditions)

Related publications that referenced our studies

Yang Y, Teja S, Baig K, "Bilateral corneal edema associated with amantadine", Canadian Medical Association Journal, 2015 Oct .
Cattoni J, Parekh R, "Acute respiratory distress syndrome: A rare presentation of amantadine toxicity", The American journal of case reports, 2012 Jan .
Yang Y, Teja S, Baig K, "Bilateral corneal edema associated with amantadine", Canadian Medical Association Journal, 2015 Oct .
Cattoni J, Parekh R, "Acute respiratory distress syndrome: A rare presentation of amantadine toxicity", The American journal of case reports, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on amantadine hydrochloride (the active ingredients of Symmetrel) and Symmetrel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.