Symproic and Constipation - a phase IV clinical study of FDA data

Summary:

Constipation is reported as a side effect among people who take Symproic (naldemedine tosylate), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Oxycodone, and have Cancer pain.

The phase IV clinical study analyzes which people have Constipation when taking Symproic. It is created by eHealthMe based on reports of 1,485 people who have side effects when taking Symproic from the FDA, and is updated regularly.

What is Symproic?

Symproic has active ingredients of naldemedine tosylate. eHealthMe is studying from 1,487 Symproic users. Check the latest studies of Symproic.

What is Constipation?

Constipation is found to be associated with 3,004 drugs and 4,618 conditions by eHealthMe. Check the latest studies of Constipation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 24, 2026

1,485 people reported to have side effects when taking Symproic.
Among them, 93 people (6.26%) have Constipation.

Among these 93 people:

How long have people been on Symproic when they have Constipation? *

What is the gender of people who have Constipation when taking Symproic? *

female: 56.82 %
male: 43.18 %

What is the age of people who have Constipation when taking Symproic? *

What are other drugs people take besides Symproic? *

Oxycodone: 23 people, 24.73%
Magnesium Oxide: 21 people, 22.58%
Oxycodone Hydrochloride: 20 people, 21.51%
Amlodipine: 14 people, 15.05%
Oxycontin: 13 people, 13.98%
Dexamethasone Sodium Phosphate: 10 people, 10.75%
Emend: 10 people, 10.75%
Aprepitant: 9 people, 9.68%
Carboplatin: 9 people, 9.68%
Hydromorphone Hydrochloride: 8 people, 8.60%

What are other side effects people have besides Constipation? *

Diarrhea: 15 people, 16.13%
Nausea (feeling of having an urge to vomit): 15 people, 16.13%
Delirium (wild excitement): 13 people, 13.98%
Fever: 13 people, 13.98%
Malaise (a feeling of general discomfort or uneasiness): 12 people, 12.90%
Thrombocytopenia (decrease of platelets in blood): 10 people, 10.75%
Nausea And Vomiting: 8 people, 8.60%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 8 people, 8.60%
Drowsiness: 8 people, 8.60%
Drug Ineffective: 8 people, 8.60%

What are the existing conditions these people have? *

Cancer Pain: 20 people, 21.51%
Pain: 11 people, 11.83%
High Blood Pressure: 7 people, 7.53%
Non-Small Cell Lung Cancer Recurrent (type of epithelial lung cancer reoccurrence): 6 people, 6.45%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 5 people, 5.38%
Depression: 5 people, 5.38%
Drowsiness: 4 people, 4.30%
Back Pain: 4 people, 4.30%
Thermal Burn (burn by heat): 4 people, 4.30%
Delirium (wild excitement): 4 people, 4.30%

* Approximation only. Some reports may have incomplete information.

Do you take Symproic and have Constipation?

- Check whether Constipation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Symproic:

Symproic (1,487 reports)

Constipation treatments and more:

Constipation (337,880 reports)

Browse all side effects of Symproic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Constipation:

Constipation (3,004 drugs)

Browse all the conditions that are associated with Constipation:

Constipation (4,618 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naldemedine tosylate (the active ingredients of Symproic) and Symproic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.