Synephrine and Constipation - a phase IV clinical study of FDA data

Summary:

Constipation is reported as a side effect among people who take Synephrine (bitter orange), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Neurontin, and have Metastases to bone.

The phase IV clinical study analyzes which people have Constipation when taking Synephrine. It is created by eHealthMe based on reports of 244 people who have side effects when taking Synephrine from the FDA, and is updated regularly.

What is Synephrine?

Synephrine has active ingredients of bitter orange. It is often used in weight loss. eHealthMe is studying from 257 Synephrine users. Check the latest studies of Synephrine.

What is Constipation?

Constipation is found to be associated with 3,004 drugs and 4,613 conditions by eHealthMe. Check the latest studies of Constipation.

On Jul, 24, 2026

244 people reported to have side effects when taking Synephrine.
Among them, 13 people (5.33%) have Constipation.

Among these 13 people:

How long have people been on Synephrine when they have Constipation? *

What is the gender of people who have Constipation when taking Synephrine? *

female: 7.69 %
male: 92.31 %

What is the age of people who have Constipation when taking Synephrine? *

What are other drugs people take besides Synephrine? *

What are other side effects people have besides Constipation? *

Wound Secretion: 12 people, 92.31%
Eye Pain: 12 people, 92.31%
Gastroenteritis (inflammation of stomach and intestine): 12 people, 92.31%
Gastroenteritis Radiation (radiation induced inflammation of stomach and intestine): 12 people, 92.31%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 92.31%
Gastrointestinal Motility Disorder (abnormal intestinal contractions): 12 people, 92.31%
General Physical Health Deterioration (weak health status): 12 people, 92.31%
Gingival Disorder (gum disease): 12 people, 92.31%
Granulomatous Liver Disease (a mass of inflamed granulation tissue of liver): 12 people, 92.31%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 12 people, 92.31%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 12 people, 92.31%
Gout (uric acid crystals building up in the body): 11 people, 84.62%
Cuts And Puncture Wounds: 9 people, 69.23%
Wound: 2 people, 15.38%
Sedation: 1 person, 7.69%
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 1 person, 7.69%
Adjustment Disorder: 1 person, 7.69%
Anaemia (lack of blood): 1 person, 7.69%
Anaesthesia: 1 person, 7.69%
Cough: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Synephrine and have Constipation?

- Check whether Constipation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Synephrine:

Synephrine (257 reports)

Constipation treatments and more:

Constipation (337,879 reports)

Browse all side effects of Synephrine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Constipation:

Constipation (3,004 drugs)

Browse all the conditions that are associated with Constipation:

Constipation (4,613 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bitter orange (the active ingredients of Synephrine) and Synephrine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.