1. Home
  2. Analysis
  3. Synephrine
  4. Headache

Synephrine and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Synephrine (bitter orange), especially for people who are female, 50-59 old, also take Flolan, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Headache when taking Synephrine. It is created by eHealthMe based on reports of 244 people who have side effects when taking Synephrine from the FDA, and is updated regularly.

What is Synephrine?

Synephrine has active ingredients of bitter orange. It is often used in weight loss. eHealthMe is studying from 257 Synephrine users. Check the latest studies of Synephrine.

What is Headache?

Headache (pain in head) is found to be associated with 3,746 drugs and 5,768 conditions by eHealthMe. Check the latest studies of Headache.

On Jul, 11, 2026

244 people reported to have side effects when taking Synephrine.
Among them, 18 people (7.38%) have Headache.

Could Synephrine cause Headache?

Among these 18 people:

What is the gender of people who have Headache when taking Synephrine? *

  • female: 56.25 %
  • male: 43.75 %

What is the age of people who have Headache when taking Synephrine? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 33.33 %
  • 20-29: 0.0 %
  • 30-39: 6.67 %
  • 40-49: 0.0 %
  • 50-59: 40.0 %
  • 60+: 20.0 %

What are other drugs people take besides Synephrine? *

  1. Decadron: 6 people, 33.33%
  2. Levophed: 6 people, 33.33%
  3. Tylenol: 6 people, 33.33%
  4. Vasopressin: 6 people, 33.33%
  5. Benadryl: 6 people, 33.33%
  6. Flolan: 6 people, 33.33%
  7. Marcaine: 5 people, 27.78%
  8. Lysteda: 5 people, 27.78%
  9. Zyloprim: 5 people, 27.78%
  10. Klor-Con: 5 people, 27.78%

What are other side effects people have besides Headache? *

  1. Lung Disorder (lung disease): 7 people, 38.89%
  2. Fatigue (feeling of tiredness): 7 people, 38.89%
  3. Abdominal Pain: 7 people, 38.89%
  4. Joint Pain: 6 people, 33.33%
  5. Muscle Spasms (muscle contraction): 6 people, 33.33%
  6. Nausea (feeling of having an urge to vomit): 6 people, 33.33%
  7. Hypotension (abnormally low blood pressure): 6 people, 33.33%
  8. Pain In Extremity: 6 people, 33.33%
  9. Pain In Jaw: 6 people, 33.33%
  10. Chest Pain: 6 people, 33.33%

What are the existing conditions these people have? *

  1. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 33.33%
  2. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 27.78%
  3. Retinal Oedema (swelling of retina): 1 person, 5.56%
  4. Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 1 person, 5.56%
  5. Blood Immunoglobulin E Increased: 1 person, 5.56%
  6. Asthma: 1 person, 5.56%
  7. Anaesthesia: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Synephrine and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Synephrine:

Headache treatments and more:

How severe was Headache and when was it recovered:

Expand to all the drugs that have ingredients of bitter orange:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Synephrine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Browse all the conditions that are associated with Headache:

How the study uses the data?

The study uses data from the FDA. It is based on bitter orange (the active ingredients of Synephrine) and Synephrine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.