Tacrolimus and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Tacrolimus (tacrolimus), especially for people who are male, 50-59 old, have been taking the drug for 1 - 6 months also take Multivitamin, and have Dermatitis atopic.

The phase IV clinical study analyzes which people have Major depression when taking Tacrolimus. It is created by eHealthMe based on reports of 115,828 people who have side effects when taking Tacrolimus from the FDA, and is updated regularly.

What is Tacrolimus?

Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 116,161 Tacrolimus users. Check the latest studies of Tacrolimus.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 798 drugs and 1,478 conditions by eHealthMe. Check the latest studies of Major depression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

115,828 people reported to have side effects when taking Tacrolimus.
Among them, 29 people (0.03%) have Major depression.

Could Tacrolimus cause Major depression?

Among these 29 people:

How long have people been on Tacrolimus when they have Major depression? *

What is the gender of people who have Major depression when taking Tacrolimus? *

female: 47.83 %
male: 52.17 %

What is the age of people who have Major depression when taking Tacrolimus? *

What are other drugs people take besides Tacrolimus? *

What are other side effects people have besides Major depression? *

Diarrhea: 8 people, 27.59%
Pain: 8 people, 27.59%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 24.14%
Renal Impairment (severely reduced kidney function): 7 people, 24.14%
Headache (pain in head): 6 people, 20.69%
Haemorrhage (bleeding): 5 people, 17.24%
Suicidal Ideation: 5 people, 17.24%
Dyspnea (difficult or laboured breathing): 5 people, 17.24%
Death: 5 people, 17.24%
High Blood Pressure: 5 people, 17.24%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 13.79%
Keratosis Follicular (a condition in which there are numerous rough follicular spots, which may be skin coloured, red or brown): 4 people, 13.79%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 4 people, 13.79%
Thrombocytopenia (decrease of platelets in blood): 3 people, 10.34%
Immunodeficiency Disorders: 3 people, 10.34%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 2 people, 6.90%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 3.45%
Stress And Anxiety: 1 person, 3.45%
Stomatitis (inflammation of mucous membrane of mouth): 1 person, 3.45%
Sinusitis (inflammation of sinus): 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Tacrolimus and have Major depression?

- Check whether Major depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tacrolimus:

Tacrolimus (116,161 reports)

Major depression treatments and more:

Major depression (44,987 reports)

Browse all side effects of Tacrolimus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (798 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,478 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tacrolimus (the active ingredients of Tacrolimus) and Tacrolimus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.