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Tarka and Hyponatremia - a phase IV clinical study of FDA data

Summary:

Hyponatremia is reported as a side effect among people who take Tarka (trandolapril; verapamil hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Paracetamol, and have Poisoning deliberate.

The phase IV clinical study analyzes which people have Hyponatremia when taking Tarka. It is created by eHealthMe based on reports of 2,361 people who have side effects when taking Tarka from the FDA, and is updated regularly.

What is Tarka?

Tarka has active ingredients of trandolapril; verapamil hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 2,409 Tarka users. Check the latest studies of Tarka.

What is Hyponatremia?

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration) is found to be associated with 1,940 drugs and 2,272 conditions by eHealthMe. Check the latest studies of Hyponatremia.

On Jul, 13, 2026

2,361 people reported to have side effects when taking Tarka.
Among them, 32 people (1.36%) have Hyponatremia.

Could Tarka cause Hyponatremia?

Among these 32 people:

How long have people been on Tarka when they have Hyponatremia? *

  • < 1 month: 64.29 %
  • 1 - 6 months: 28.57 %
  • 6 - 12 months: 7.14 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hyponatremia when taking Tarka? *

  • female: 90.62 %
  • male: 9.38 %

What is the age of people who have Hyponatremia when taking Tarka? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 22.58 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 3.23 %
  • 50-59: 3.23 %
  • 60+: 70.97 %

What are other drugs people take besides Tarka? *

  1. Paracetamol: 7 people, 21.88%
  2. Acetaminophen: 5 people, 15.62%
  3. Xanax: 4 people, 12.50%
  4. Hydrochlorothiazide: 3 people, 9.38%
  5. Aldactone: 3 people, 9.38%
  6. Mavik: 3 people, 9.38%
  7. Nexium: 2 people, 6.25%
  8. Isoptin Sr: 2 people, 6.25%
  9. Haldol: 2 people, 6.25%
  10. Lantus: 2 people, 6.25%

What are other side effects people have besides Hyponatremia? *

  1. Drowsiness: 10 people, 31.25%
  2. Acute Kidney Failure: 9 people, 28.12%
  3. Hypotension (abnormally low blood pressure): 8 people, 25.00%
  4. Bradycardia (abnormally slow heart action): 7 people, 21.88%
  5. Bradypnea: 7 people, 21.88%
  6. Coughing Up Blood: 7 people, 21.88%
  7. Dermatitis Exfoliative Generalised (inflammatory skin disease with erythema and scaling that affects nearly the entire cutaneous surface): 7 people, 21.88%
  8. Hepatocellular Injury (liver injury): 7 people, 21.88%
  9. Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light): 7 people, 21.88%
  10. Hyperkalemia (damage to or disease of the kidney): 6 people, 18.75%

What are the existing conditions these people have? *

  1. Poisoning Deliberate: 4 people, 12.50%
  2. Psychotic Disorder: 2 people, 6.25%
  3. Joint Pain: 2 people, 6.25%
  4. Diarrhea: 2 people, 6.25%
  5. Depression: 2 people, 6.25%
  6. Bipolar Disorder (mood disorder): 2 people, 6.25%
  7. Back Pain: 2 people, 6.25%
  8. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 6.25%
  9. Abdominal Pain Upper: 2 people, 6.25%
  10. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Tarka and have Hyponatremia?

- Check whether Hyponatremia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tarka:

Hyponatremia treatments and more:

How severe was Hyponatremia and when was it recovered:

Expand to all the drugs that have ingredients of trandolapril; verapamil hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tarka:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatremia:

Browse all the conditions that are associated with Hyponatremia:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on trandolapril; verapamil hydrochloride (the active ingredients of Tarka) and Tarka (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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