Taxol and Second primary malignancy - a phase IV clinical study of FDA data

Summary:

Second primary malignancy is reported as a side effect among people who take Taxol (paclitaxel), especially for people who are female, 30-39 old, have been taking the drug for 1 - 6 months also take Taxotere, and have Gestational trophoblastic disease.

The phase IV clinical study analyzes which people have Second primary malignancy when taking Taxol. It is created by eHealthMe based on reports of 33,313 people who have side effects when taking Taxol from the FDA, and is updated regularly.

What is Taxol?

Taxol has active ingredients of paclitaxel. It is often used in breast cancer. eHealthMe is studying from 33,554 Taxol users. Check the latest studies of Taxol.

What is Second primary malignancy?

Second primary malignancy (after getting cure a cancer, a new cancer development) is found to be associated with 539 drugs and 466 conditions by eHealthMe. Check the latest studies of Second primary malignancy.

On Jun, 12, 2026

33,313 people reported to have side effects when taking Taxol.
Among them, 76 people (0.23%) have Second primary malignancy.

Could Taxol cause Second primary malignancy?

Among these 76 people:

How long have people been on Taxol when they have Second primary malignancy? *

What is the gender of people who have Second primary malignancy when taking Taxol? *

female: 87.69 %
male: 12.31 %

What is the age of people who have Second primary malignancy when taking Taxol? *

What are other drugs people take besides Taxol? *

Taxotere: 46 people, 60.53%
Dactinomycin: 31 people, 40.79%
Cosmegen: 28 people, 36.84%
Methotrexate: 14 people, 18.42%
Zometa: 14 people, 18.42%
Cisplatin: 12 people, 15.79%
Doxorubicin Hydrochloride: 12 people, 15.79%
Cyclophosphamide: 11 people, 14.47%
Vincristine Sulfate: 11 people, 14.47%
Etoposide: 11 people, 14.47%

What are other side effects people have besides Second primary malignancy? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 41 people, 53.95%
Osteonecrosis Of Jaw (death of bone of jaw): 14 people, 18.42%
Nausea (feeling of having an urge to vomit): 14 people, 18.42%
Anaemia (lack of blood): 12 people, 15.79%
Pain: 11 people, 14.47%
Fatigue (feeling of tiredness): 11 people, 14.47%
Metastases To Bone (cancer spreads to bone): 11 people, 14.47%
Stress And Anxiety: 11 people, 14.47%
Nausea And Vomiting: 10 people, 13.16%
Rashes (redness): 10 people, 13.16%

What are the existing conditions these people have? *

Gestational Trophoblastic Disease (disease of foetus surrounding during pregnancy): 37 people, 48.68%
Metastatic Choriocarcinoma (cancer of embryo covering cells can spread to other part): 25 people, 32.89%
Metastatic Neoplasm (spreadable cancer tumour): 22 people, 28.95%
Metastases To Central Nervous System (cancer spreads to central nervous system): 16 people, 21.05%
Metastases To Skin (cancer spreads to skin): 16 people, 21.05%
Recurrent Cancer (repeated cancer): 16 people, 21.05%
Metastases To Lung (cancer spreads to lung): 15 people, 19.74%
Metastases To Bone (cancer spreads to bone): 6 people, 7.89%
Breast Cancer Metastatic: 6 people, 7.89%
Pain: 4 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Taxol and have Second primary malignancy?

- Check whether Second primary malignancy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Taxol:

Taxol (33,554 reports)

Browse all side effects of Taxol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Second primary malignancy:

Second primary malignancy (539 drugs)

Browse all the conditions that are associated with Second primary malignancy:

Second primary malignancy (466 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on paclitaxel (the active ingredients of Taxol) and Taxol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.