Tecfidera and Tendon rupture - a phase IV clinical study of FDA data

Summary:

Tendon rupture is reported as a side effect among people who take Tecfidera (dimethyl fumarate), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Ampyra, and have Gait disturbance.

The phase IV clinical study analyzes which people have Tendon rupture when taking Tecfidera. It is created by eHealthMe based on reports of 129,391 people who have side effects when taking Tecfidera from the FDA, and is updated regularly.

What is Tecfidera?

Tecfidera has active ingredients of dimethyl fumarate. It is often used in multiple sclerosis. eHealthMe is studying from 129,627 Tecfidera users. Check the latest studies of Tecfidera.

What is Tendon rupture?

Tendon rupture (tear of tendon) is found to be associated with 804 drugs and 1,060 conditions by eHealthMe. Check the latest studies of Tendon rupture.

On Jul, 14, 2026

129,391 people reported to have side effects when taking Tecfidera.
Among them, 56 people (0.04%) have Tendon rupture.

Among these 56 people:

How long have people been on Tecfidera when they have Tendon rupture? *

What is the gender of people who have Tendon rupture when taking Tecfidera? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Tendon rupture when taking Tecfidera? *

What are other drugs people take besides Tecfidera? *

What are other side effects people have besides Tendon rupture? *

Fall: 25 people, 44.64%
Rotator Cuff Syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 16 people, 28.57%
Memory Loss: 13 people, 23.21%
Fatigue (feeling of tiredness): 11 people, 19.64%
Gait Disturbance: 10 people, 17.86%
Nausea (feeling of having an urge to vomit): 9 people, 16.07%
Stress And Anxiety: 8 people, 14.29%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 8 people, 14.29%
Mobility Decreased (ability to move is reduced): 7 people, 12.50%
Pneumonia: 7 people, 12.50%

What are the existing conditions these people have? *

Gait Disturbance: 9 people, 16.07%
Urinary Retention (the inability to completely or partially empty the bladder): 4 people, 7.14%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 7.14%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 7.14%
Neuralgia (pain in one or more nerves): 3 people, 5.36%
Pain: 2 people, 3.57%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 3.57%
Prostate Cancer: 1 person, 1.79%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 1.79%
Joint Pain: 1 person, 1.79%

* Approximation only. Some reports may have incomplete information.

Do you take Tecfidera and have Tendon rupture?

- Check whether Tendon rupture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tecfidera:

Tecfidera (129,627 reports)

Tendon rupture treatments and more:

Tendon rupture (15,907 reports)

Browse all side effects of Tecfidera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tendon rupture:

Tendon rupture (804 drugs)

Browse all the conditions that are associated with Tendon rupture:

Tendon rupture (1,060 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dimethyl fumarate (the active ingredients of Tecfidera) and Tecfidera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.