Tegsedi and Mean cell haemoglobin concentration increased - a phase IV clinical study of FDA data

Summary:

Mean cell haemoglobin concentration increased is reported as a side effect among people who take Tegsedi (inotersen sodium), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Aspirin, and have Hereditary neuropathic amyloidosis.

The phase IV clinical study analyzes which people have Mean cell haemoglobin concentration increased when taking Tegsedi. It is created by eHealthMe based on reports of 2,040 people who have side effects when taking Tegsedi from the FDA, and is updated regularly.

What is Tegsedi?

Tegsedi has active ingredients of inotersen sodium. eHealthMe is studying from 2,040 Tegsedi users. Check the latest studies of Tegsedi.

What is Mean cell haemoglobin concentration increased?

Mean cell haemoglobin concentration increased (more concentration of haemoglobin in a given volume of packed red blood cells) is found to be associated with 130 drugs and 241 conditions by eHealthMe. Check the latest studies of Mean cell haemoglobin concentration increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

2,040 people reported to have side effects when taking Tegsedi.
Among them, 18 people (0.88%) have Mean cell haemoglobin concentration increased.

Could Tegsedi cause Mean cell haemoglobin concentration increased?

Among these 18 people:

How long have people been on Tegsedi when they have Mean cell haemoglobin concentration increased? *

What is the gender of people who have Mean cell haemoglobin concentration increased when taking Tegsedi? *

female: 40 %
male: 60 %

What is the age of people who have Mean cell haemoglobin concentration increased when taking Tegsedi? *

What are other drugs people take besides Tegsedi? *

Aspirin: 6 people, 33.33%
Pregabalin: 5 people, 27.78%
Spironolactone: 3 people, 16.67%
Furosemide: 3 people, 16.67%
Lasix: 3 people, 16.67%
Midodrine Hydrochloride: 3 people, 16.67%
Acetaminophen: 2 people, 11.11%
Clopidogrel: 2 people, 11.11%
Cordarone: 2 people, 11.11%
Crestor: 2 people, 11.11%

What are other side effects people have besides Mean cell haemoglobin concentration increased? *

Thrombocytopenia (decrease of platelets in blood): 17 people, 94.44%
Red Blood Cell Count Decreased: 10 people, 55.56%
Mean Cell Haemoglobin Increased (more than normal haemoglobin per red blood cell in a sample of blood): 10 people, 55.56%
Haemoglobin Decreased: 9 people, 50.00%
Haematocrit Decreased: 9 people, 50.00%
Hypotension (abnormally low blood pressure): 9 people, 50.00%
Glomerular Filtration Rate Decreased: 8 people, 44.44%
Urine Protein/creatinine Ratio Increased: 7 people, 38.89%
Weakness: 7 people, 38.89%
Pain: 6 people, 33.33%

What are the existing conditions these people have? *

Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 14 people, 77.78%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 3 people, 16.67%
Magnesium Deficiency (lack of magnesium): 2 people, 11.11%
Glaucoma (increased fluid pressure in the eye with vision loss): 2 people, 11.11%
Hypotension (abnormally low blood pressure): 2 people, 11.11%
Incontinence (lack of moderation or self-control): 2 people, 11.11%
Influenza Like Illness: 2 people, 11.11%
Addison's Disease (addison's disease, a hormonal disorder disease): 2 people, 11.11%
Neuralgia (pain in one or more nerves): 2 people, 11.11%
Cardiac Disorder: 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Tegsedi and have Mean cell haemoglobin concentration increased?

- Check whether Mean cell haemoglobin concentration increased is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tegsedi:

Tegsedi (2,040 reports)

Mean cell haemoglobin concentration increased treatments and more:

Mean cell haemoglobin concentration increased (775 reports)

How severe was Mean cell haemoglobin concentration increased and when was it recovered:

Mean cell haemoglobin concentration increased in Tegsedi

Expand to all the drugs that have ingredients of inotersen sodium:

Mean cell haemoglobin concentration increased and drugs with ingredients of inotersen sodium

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tegsedi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mean cell haemoglobin concentration increased:

Mean cell haemoglobin concentration increased (130 drugs)

Browse all the conditions that are associated with Mean cell haemoglobin concentration increased:

Mean cell haemoglobin concentration increased (241 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on inotersen sodium (the active ingredients of Tegsedi) and Tegsedi (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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