Tegsedi and Mean platelet volume increased - a phase IV clinical study of FDA data

Summary:

Mean platelet volume increased is reported as a side effect among people who take Tegsedi (inotersen sodium), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Pregabalin, and have Hereditary neuropathic amyloidosis.

The phase IV clinical study analyzes which people have Mean platelet volume increased when taking Tegsedi. It is created by eHealthMe based on reports of 2,040 people who have side effects when taking Tegsedi from the FDA, and is updated regularly.

What is Tegsedi?

Tegsedi has active ingredients of inotersen sodium. eHealthMe is studying from 2,040 Tegsedi users. Check the latest studies of Tegsedi.

What is Mean platelet volume increased?

Mean platelet volume increased (more than normal average size of platelet cells in blood) is found to be associated with 118 drugs and 194 conditions by eHealthMe. Check the latest studies of Mean platelet volume increased.

On Aug, 08, 2026

2,040 people reported to have side effects when taking Tegsedi.
Among them, 14 people (0.69%) have Mean platelet volume increased.

Could Tegsedi cause Mean platelet volume increased?

Among these 14 people:

How long have people been on Tegsedi when they have Mean platelet volume increased? *

What is the gender of people who have Mean platelet volume increased when taking Tegsedi? *

female: 100 %
male: 0.0 %

What is the age of people who have Mean platelet volume increased when taking Tegsedi? *

What are other drugs people take besides Tegsedi? *

What are other side effects people have besides Mean platelet volume increased? *

Thrombocytopenia (decrease of platelets in blood): 12 people, 85.71%
Protein Urine Present: 10 people, 71.43%
Red Blood Cell Count Decreased: 10 people, 71.43%
Haemoglobin Decreased: 10 people, 71.43%
Haematocrit Decreased: 9 people, 64.29%
Mean Cell Haemoglobin Concentration Decreased (less concentration of haemoglobin in a given volume of packed red blood cells): 8 people, 57.14%
Lymphocyte Count Decreased: 8 people, 57.14%
Crystal Urine Present: 7 people, 50.00%
Weakness: 7 people, 50.00%
Blood Creatinine Increased: 7 people, 50.00%

What are the existing conditions these people have? *

Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 12 people, 85.71%
High Blood Pressure: 7 people, 50.00%
Neuralgia (pain in one or more nerves): 4 people, 28.57%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 21.43%
Gout (uric acid crystals building up in the body): 3 people, 21.43%
Enlarged Prostate: 3 people, 21.43%
Peripheral Arterial Occlusive Disease (reproducible ischemic muscle pain): 3 people, 21.43%
Oedema (fluid collection in tissue): 2 people, 14.29%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 14.29%
Diabetes: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Tegsedi and have Mean platelet volume increased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tegsedi:

Tegsedi (2,040 reports)

Browse all side effects of Tegsedi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mean platelet volume increased:

Mean platelet volume increased (118 drugs)

Browse all the conditions that are associated with Mean platelet volume increased:

Mean platelet volume increased (194 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on inotersen sodium (the active ingredients of Tegsedi) and Tegsedi (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.