Temodar and Hyponatraemia aggravated - a phase IV clinical study of FDA data

Summary:

Hyponatraemia aggravated is reported as a side effect among people who take Temodar (temozolomide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Decadron, and have Glioblastoma.

The phase IV clinical study analyzes which people have Hyponatraemia aggravated when taking Temodar. It is created by eHealthMe based on reports of 6,563 people who have side effects when taking Temodar from the FDA, and is updated regularly.

What is Temodar?

Temodar has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 6,683 Temodar users. Check the latest studies of Temodar.

What is Hyponatraemia aggravated?

Hyponatraemia aggravated (abnormally low concentrations of sodium ions in the circulating blood) is found to be associated with 1,510 drugs and 543 conditions by eHealthMe. Check the latest studies of Hyponatraemia aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

6,563 people reported to have side effects when taking Temodar.
Among them, 69 people (1.05%) have Hyponatraemia aggravated.

Could Temodar cause Hyponatraemia aggravated?

Among these 69 people:

How long have people been on Temodar when they have Hyponatraemia aggravated? *

What is the gender of people who have Hyponatraemia aggravated when taking Temodar? *

female: 54.69 %
male: 45.31 %

What is the age of people who have Hyponatraemia aggravated when taking Temodar? *

What are other drugs people take besides Temodar? *

What are other side effects people have besides Hyponatraemia aggravated? *

Fatigue (feeling of tiredness): 19 people, 27.54%
Hyperglycemia (high blood sugar): 18 people, 26.09%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 17 people, 24.64%
Anaemia (lack of blood): 15 people, 21.74%
Dehydration (dryness resulting from the removal of water): 15 people, 21.74%
Thrombocytopenia (decrease of platelets in blood): 13 people, 18.84%
Pneumonia: 12 people, 17.39%
Diarrhea: 12 people, 17.39%
Weakness: 11 people, 15.94%
Nausea (feeling of having an urge to vomit): 11 people, 15.94%

What are the existing conditions these people have? *

Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 7 people, 10.14%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 5.80%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 3 people, 4.35%
Malignant Melanoma (skin cancer rises from melancytes): 3 people, 4.35%
Ewing's Sarcoma Metastatic (malignant small, round, blue cell tumour-metastatic): 2 people, 2.90%
Nausea (feeling of having an urge to vomit): 2 people, 2.90%
Gliosarcoma (a cancer of the brain that comes from glial, or supportive, brain cells): 2 people, 2.90%
Ill-Defined Disorder: 1 person, 1.45%
Astrocytoma (tumour of the brain that originate in a particular kind of glial-cells): 1 person, 1.45%
Depression: 1 person, 1.45%

* Approximation only. Some reports may have incomplete information.

Do you take Temodar and have Hyponatraemia aggravated?

- Check whether Hyponatraemia aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Temodar:

Temodar (6,683 reports)

Browse all side effects of Temodar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatraemia aggravated:

Hyponatraemia aggravated (1,510 drugs)

Browse all the conditions that are associated with Hyponatraemia aggravated:

Hyponatraemia aggravated (543 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on temozolomide (the active ingredients of Temodar) and Temodar (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.