Temodar and Mental status changes - a phase IV clinical study of FDA data

Summary:

Mental status changes is reported as a side effect among people who take Temodar (temozolomide), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Decadron, and have Glioblastoma.

The phase IV clinical study analyzes which people have Mental status changes when taking Temodar. It is created by eHealthMe based on reports of 6,563 people who have side effects when taking Temodar from the FDA, and is updated regularly.

What is Temodar?

Temodar has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 6,683 Temodar users. Check the latest studies of Temodar.

What is Mental status changes?

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) is found to be associated with 1,496 drugs and 1,760 conditions by eHealthMe. Check the latest studies of Mental status changes.

On Jul, 28, 2026

6,563 people reported to have side effects when taking Temodar.
Among them, 96 people (1.46%) have Mental status changes.

Could Temodar cause Mental status changes?

Among these 96 people:

How long have people been on Temodar when they have Mental status changes? *

What is the gender of people who have Mental status changes when taking Temodar? *

female: 41.94 %
male: 58.06 %

What is the age of people who have Mental status changes when taking Temodar? *

What are other drugs people take besides Temodar? *

What are other side effects people have besides Mental status changes? *

Confusional State: 29 people, 30.21%
Pneumonia: 20 people, 20.83%
Thrombocytopenia (decrease of platelets in blood): 19 people, 19.79%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 18 people, 18.75%
Swallowing Difficulty: 16 people, 16.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 15 people, 15.62%
Pain: 15 people, 15.62%
Fever: 15 people, 15.62%
Depression: 15 people, 15.62%
Weakness: 14 people, 14.58%

What are the existing conditions these people have? *

Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 14 people, 14.58%
Metastases To Central Nervous System (cancer spreads to central nervous system): 8 people, 8.33%
Oligodendroglioma (a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell): 6 people, 6.25%
Brain Neoplasm Malignant (brain cancer tumour): 5 people, 5.21%
Astrocytoma (tumour of the brain that originate in a particular kind of glial-cells): 4 people, 4.17%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 4 people, 4.17%
Urinary Tract Infection: 3 people, 3.12%
Brain Neoplasm (tumour of brain): 3 people, 3.12%
Depression: 3 people, 3.12%
Glioma (a type of tumour that starts in the brain or spine): 3 people, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Temodar and have Mental status changes?

- Check whether Mental status changes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Temodar:

Temodar (6,683 reports)

Browse all side effects of Temodar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mental status changes:

Mental status changes (1,496 drugs)

Browse all the conditions that are associated with Mental status changes:

Mental status changes (1,760 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on temozolomide (the active ingredients of Temodar) and Temodar (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.