Temozolomide and Insomnia - a phase IV clinical study of FDA data

Summary:

Insomnia is reported as a side effect among people who take Temozolomide (temozolomide), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Afinitor, and have Paraganglion neoplasm malignant.

The phase IV clinical study analyzes which people have Insomnia when taking Temozolomide. It is created by eHealthMe based on reports of 16,598 people who have side effects when taking Temozolomide from the FDA, and is updated regularly.

What is Temozolomide?

Temozolomide has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 16,644 Temozolomide users. Check the latest studies of Temozolomide.

What is Insomnia?

Insomnia (sleeplessness) is found to be associated with 3,115 drugs and 5,173 conditions by eHealthMe. Check the latest studies of Insomnia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 04, 2026

16,598 people reported to have side effects when taking Temozolomide.
Among them, 75 people (0.45%) have Insomnia.

Among these 75 people:

How long have people been on Temozolomide when they have Insomnia? *

What is the gender of people who have Insomnia when taking Temozolomide? *

female: 61.76 %
male: 38.24 %

What is the age of people who have Insomnia when taking Temozolomide? *

What are other drugs people take besides Temozolomide? *

Afinitor: 18 people, 24.00%
Avastin: 7 people, 9.33%
Ondansetron: 6 people, 8.00%
Claritin: 5 people, 6.67%
Voltaren: 4 people, 5.33%
Lipitor: 3 people, 4.00%
Oxycodone: 2 people, 2.67%
Clindamycin Phosphate: 2 people, 2.67%
Prochlorperazine Edisylate: 2 people, 2.67%
Sandostatin: 2 people, 2.67%

What are other side effects people have besides Insomnia? *

Headache (pain in head): 28 people, 37.33%
Nausea (feeling of having an urge to vomit): 23 people, 30.67%
Fatigue (feeling of tiredness): 23 people, 30.67%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 20 people, 26.67%
Constipation: 15 people, 20.00%
Diarrhea: 14 people, 18.67%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 14 people, 18.67%
Metastases To Bone (cancer spreads to bone): 13 people, 17.33%
Metastases To Liver (cancer spreads to liver): 13 people, 17.33%
Metastases To Central Nervous System (cancer spreads to central nervous system): 13 people, 17.33%

What are the existing conditions these people have? *

Paraganglion Neoplasm Malignant (paraganglion cancerous tumour): 19 people, 25.33%
Phaeochromocytoma (vascular tumour of the adrenal gland): 13 people, 17.33%
Anaplastic Astrocytoma (tumour of the glial (supportive) tissue of the brain): 7 people, 9.33%
Neoplasm Malignant (cancer tumour): 7 people, 9.33%
Neuroendocrine Tumor: 4 people, 5.33%
Nausea (feeling of having an urge to vomit): 3 people, 4.00%
Central Nervous System Lymphoma (cancer of central nervous system forms in lymph tissue): 3 people, 4.00%
Brain Neoplasm Malignant (brain cancer tumour): 3 people, 4.00%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 2 people, 2.67%
Depression: 2 people, 2.67%

* Approximation only. Some reports may have incomplete information.

Do you take Temozolomide and have Insomnia?

- Check whether Insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Temozolomide:

Temozolomide (16,644 reports)

Insomnia treatments and more:

Insomnia (438,081 reports)

Browse all side effects of Temozolomide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Insomnia:

Insomnia (3,115 drugs)

Browse all the conditions that are associated with Insomnia:

Insomnia (5,173 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on temozolomide (the active ingredients of Temozolomide) and Temozolomide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.