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Tepezza and Functional colitis - a phase IV clinical study of FDA data

Summary:

Functional colitis is reported as a side effect among people who take Tepezza (teprotumumab-trbw), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Synthroid, and have Endocrine ophthalmopathy.

The phase IV clinical study analyzes which people have Functional colitis when taking Tepezza. It is created by eHealthMe based on reports of 3,630 people who have side effects when taking Tepezza from the FDA, and is updated regularly.

What is Tepezza?

Tepezza has active ingredients of teprotumumab-trbw. eHealthMe is studying from 3,632 Tepezza users. Check the latest studies of Tepezza.

What is Functional colitis?

Functional colitis (the muscles in the colon do not work normally and may spasm) is found to be associated with 2,139 drugs and 2,154 conditions by eHealthMe. Check the latest studies of Functional colitis.

On Apr, 13, 2026

3,630 people reported to have side effects when taking Tepezza.
Among them, 29 people (0.8%) have Functional colitis.

Could Tepezza cause Functional colitis?

Among these 29 people:

How long have people been on Tepezza when they have Functional colitis? *

  • < 1 month: 50 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Functional colitis when taking Tepezza? *

  • female: 66.67 %
  • male: 33.33 %

What is the age of people who have Functional colitis when taking Tepezza? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 50 %
  • 40-49: 50 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Tepezza? *

  1. Metformin: 3 people, 10.34%
  2. Synthroid: 3 people, 10.34%
  3. Dicyclomine Hydrochloride: 2 people, 6.90%
  4. Methimazole: 2 people, 6.90%
  5. Dexamethasone: 1 person, 3.45%
  6. Amlodipine Besylate: 1 person, 3.45%
  7. Atorvastatin Calcium: 1 person, 3.45%
  8. Benazepril Hydrochloride: 1 person, 3.45%
  9. Carvedilol: 1 person, 3.45%
  10. Clonidine Hydrochloride: 1 person, 3.45%

What are other side effects people have besides Functional colitis? *

  1. Fatigue (feeling of tiredness): 15 people, 51.72%
  2. Muscle Spasms (muscle contraction): 11 people, 37.93%
  3. Diarrhea: 10 people, 34.48%
  4. Blood Glucose Increased: 8 people, 27.59%
  5. Headache (pain in head): 6 people, 20.69%
  6. Weight Decreased: 5 people, 17.24%
  7. Tinnitus (a ringing in the ears): 5 people, 17.24%
  8. Pain: 5 people, 17.24%
  9. Hair Loss: 4 people, 13.79%
  10. Dry Skin: 4 people, 13.79%

What are the existing conditions these people have? *

  1. Endocrine Ophthalmopathy (increased water content of retroocular orbital tissues; associated with thyroid disease, usually hyperthyroidism): 22 people, 75.86%
  2. High Blood Pressure: 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Tepezza and have Functional colitis?

- Check whether Functional colitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tepezza:

Functional colitis treatments and more:

How severe was Functional colitis and when was it recovered:

Expand to all the drugs that have ingredients of teprotumumab-trbw:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tepezza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Functional colitis:

Browse all the conditions that are associated with Functional colitis:

How the study uses the data?

The study uses data from the FDA. It is based on teprotumumab-trbw (the active ingredients of Tepezza) and Tepezza (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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