Testosterone and Application site pain - a phase IV clinical study of FDA data

Summary:

Application site pain is reported as a side effect among people who take Testosterone (testosterone), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Prednisone, and have Night sweats.

The phase IV clinical study analyzes which people have Application site pain when taking Testosterone. It is created by eHealthMe based on reports of 5,651 people who have side effects when taking Testosterone from the FDA, and is updated regularly.

What is Testosterone?

Testosterone has active ingredients of testosterone. It is often used in testosterone. eHealthMe is studying from 6,457 Testosterone users. Check the latest studies of Testosterone.

What is Application site pain?

Application site pain is found to be associated with 561 drugs and 851 conditions by eHealthMe. Check the latest studies of Application site pain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

5,651 people reported to have side effects when taking Testosterone.
Among them, 19 people (0.34%) have Application site pain.

Could Testosterone cause Application site pain?

Among these 19 people:

How long have people been on Testosterone when they have Application site pain? *

What is the gender of people who have Application site pain when taking Testosterone? *

female: 22.22 %
male: 77.78 %

What is the age of people who have Application site pain when taking Testosterone? *

What are other drugs people take besides Testosterone? *

What are other side effects people have besides Application site pain? *

Application Site Pruritus (application site severe itching of the skin): 5 people, 26.32%
Application Site Erythema (redness of the skin at application site): 4 people, 21.05%
Application Site Irritation: 4 people, 21.05%
Application Site Vesicles (small bubble within a cell at application site): 3 people, 15.79%
Application Site Scab (hard coating on the skin formed at application site): 2 people, 10.53%
Rashes (redness): 2 people, 10.53%
Application Site Rash: 2 people, 10.53%
Testicular Pain (pain in testes): 2 people, 10.53%
Therapeutic Response Unexpected: 2 people, 10.53%
Dyspnea (difficult or laboured breathing): 2 people, 10.53%

What are the existing conditions these people have? *

Night Sweats (sweating in night): 3 people, 15.79%
Hot Flush (sudden feelings of heat): 2 people, 10.53%
Atrophic Vulvovaginitis (inflammation of the vulva): 2 people, 10.53%
Blood Testosterone Decreased: 2 people, 10.53%
High Blood Pressure: 2 people, 10.53%
Weakness: 1 person, 5.26%
Blood Testosterone Abnormal: 1 person, 5.26%
Growth Hormone Deficiency: 1 person, 5.26%
Hair Loss: 1 person, 5.26%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Testosterone and have Application site pain?

- Check whether Application site pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Testosterone:

Testosterone (6,457 reports)

Browse all side effects of Testosterone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site pain:

Application site pain (561 drugs)

Browse all the conditions that are associated with Application site pain:

Application site pain (851 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on testosterone (the active ingredients of Testosterone) and Testosterone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.