Thiola and Constipation - a phase IV clinical study of FDA data

Summary:

Constipation is reported as a side effect among people who take Thiola (tiopronin), especially for people who are female, 60+ old, also take Ranitidine, and have Cystinuria.

The phase IV clinical study analyzes which people have Constipation when taking Thiola. It is created by eHealthMe based on reports of 1,840 people who have side effects when taking Thiola from the FDA, and is updated regularly.

What is Thiola?

Thiola has active ingredients of tiopronin. eHealthMe is studying from 1,842 Thiola users. Check the latest studies of Thiola.

What is Constipation?

Constipation is found to be associated with 3,005 drugs and 4,590 conditions by eHealthMe. Check the latest studies of Constipation.

On Feb, 06, 2026

1,840 people reported to have side effects when taking Thiola.
Among them, 11 people (0.6%) have Constipation.

Among these 11 people:

What is the gender of people who have Constipation when taking Thiola? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Constipation when taking Thiola? *

What are other drugs people take besides Thiola? *

Zofran: 1 person, 9.09%
Urocit-K: 1 person, 9.09%
Seasonique: 1 person, 9.09%
Ranitidine: 1 person, 9.09%

What are other side effects people have besides Constipation? *

Drug Ineffective: 5 people, 45.45%
Lip Dry: 2 people, 18.18%
Pain: 2 people, 18.18%
Diarrhea: 2 people, 18.18%
Nausea And Vomiting: 2 people, 18.18%
Abdominal Pain: 2 people, 18.18%
Pancreatitis (inflammation of pancreas): 1 person, 9.09%
Pharyngeal Haemorrhage (pharyngeal bleeding): 1 person, 9.09%
Renal Impairment (severely reduced kidney function): 1 person, 9.09%
Nausea (feeling of having an urge to vomit): 1 person, 9.09%

What are the existing conditions these people have? *

Cystinuria (formation of cystine stones in the kidneys, ureter, and bladder): 7 people, 63.64%
Kidney Stones: 2 people, 18.18%
Cystinosis (abnormal accumulation of the amino acid cystine): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Thiola and have Constipation?

- Check whether Constipation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Thiola:

Thiola (1,842 reports)

Constipation treatments and more:

Constipation (337,868 reports)

Browse all side effects of Thiola:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Constipation:

Constipation (3,005 drugs)

Browse all the conditions that are associated with Constipation:

Constipation (4,590 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tiopronin (the active ingredients of Thiola) and Thiola (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.