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Thiola and Joint pain - a phase IV clinical study of FDA data

Summary:

Joint pain is reported as a side effect among people who take Thiola (tiopronin), especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months also take Advil Pm, and have Cystinuria.

The phase IV clinical study analyzes which people have Joint pain when taking Thiola. It is created by eHealthMe based on reports of 1,840 people who have side effects when taking Thiola from the FDA, and is updated regularly.

What is Thiola?

Thiola has active ingredients of tiopronin. eHealthMe is studying from 1,842 Thiola users. Check the latest studies of Thiola.

What is Joint pain?

Joint pain is found to be associated with 3,327 drugs and 5,212 conditions by eHealthMe. Check the latest studies of Joint pain.

On Aug, 07, 2026

1,840 people reported to have side effects when taking Thiola.
Among them, 73 people (3.97%) have Joint pain.

Could Thiola cause Joint pain?

Among these 73 people:

How long have people been on Thiola when they have Joint pain? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 28.57 %
  • 6 - 12 months: 42.86 %
  • 1 - 2 years: 28.57 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Joint pain when taking Thiola? *

  • female: 60.27 %
  • male: 39.73 %

What is the age of people who have Joint pain when taking Thiola? *

  • 0-1: 0.0 %
  • 2-9: 4.17 %
  • 10-19: 15.28 %
  • 20-29: 6.94 %
  • 30-39: 12.5 %
  • 40-49: 12.5 %
  • 50-59: 36.11 %
  • 60+: 12.5 %

What are other drugs people take besides Thiola? *

  1. Zyrtec: 2 people, 2.74%
  2. Xanax: 2 people, 2.74%
  3. Urocit-K: 2 people, 2.74%
  4. Tylenol: 2 people, 2.74%
  5. Prozac: 2 people, 2.74%
  6. Advil Pm: 2 people, 2.74%
  7. Zantac: 1 person, 1.37%
  8. Protonix: 1 person, 1.37%
  9. Neosporin: 1 person, 1.37%
  10. Minocycline: 1 person, 1.37%

What are other side effects people have besides Joint pain? *

  1. Drug Ineffective: 10 people, 13.70%
  2. Muscle Aches (muscle pain): 9 people, 12.33%
  3. Fatigue (feeling of tiredness): 9 people, 12.33%
  4. Pain In Extremity: 8 people, 10.96%
  5. Kidney Stones: 6 people, 8.22%
  6. Headache (pain in head): 5 people, 6.85%
  7. Rashes (redness): 5 people, 6.85%
  8. Head Injury: 3 people, 4.11%
  9. Itching: 3 people, 4.11%
  10. Diarrhea: 3 people, 4.11%

What are the existing conditions these people have? *

  1. Cystinuria (formation of cystine stones in the kidneys, ureter, and bladder): 50 people, 68.49%
  2. Kidney Stones: 11 people, 15.07%
  3. Unilateral Hydronephrosis (kidney stone that causes obstruction of the ureter): 2 people, 2.74%
  4. Calculus Urinary (stone in urinary system): 2 people, 2.74%
  5. Amino Acid Metabolism Disorder: 2 people, 2.74%
  6. Homocystinuria (inherited disorder in which the body is unable to process certain building blocks of proteins (amino acids) properly): 1 person, 1.37%
  7. Amino Acid Level Decreased: 1 person, 1.37%

* Approximation only. Some reports may have incomplete information.

Do you take Thiola and have Joint pain?

- Check whether Joint pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Thiola:

Joint pain treatments and more:

How severe was Joint pain and when was it recovered:

Expand to all the drugs that have ingredients of tiopronin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Thiola:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint pain:

Browse all the conditions that are associated with Joint pain:

How the study uses the data?

The study uses data from the FDA. It is based on tiopronin (the active ingredients of Thiola) and Thiola (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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