Tikosyn and Presyncope - a phase IV clinical study of FDA data

Summary:

Presyncope is reported as a side effect among people who take Tikosyn (dofetilide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin D, and have Cardiac disorder.

The phase IV clinical study analyzes which people have Presyncope when taking Tikosyn. It is created by eHealthMe based on reports of 11,814 people who have side effects when taking Tikosyn from the FDA, and is updated regularly.

What is Tikosyn?

Tikosyn has active ingredients of dofetilide. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 12,202 Tikosyn users. Check the latest studies of Tikosyn.

What is Presyncope?

Presyncope is found to be associated with 1,358 drugs and 1,288 conditions by eHealthMe. Check the latest studies of Presyncope.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

11,814 people reported to have side effects when taking Tikosyn.
Among them, 26 people (0.22%) have Presyncope.

Among these 26 people:

How long have people been on Tikosyn when they have Presyncope? *

What is the gender of people who have Presyncope when taking Tikosyn? *

female: 53.85 %
male: 46.15 %

What is the age of people who have Presyncope when taking Tikosyn? *

What are other drugs people take besides Tikosyn? *

What are other side effects people have besides Presyncope? *

Dizziness: 12 people, 46.15%
Dyspnea (difficult or laboured breathing): 9 people, 34.62%
Weakness: 8 people, 30.77%
Drug Ineffective: 5 people, 19.23%
Hypotension (abnormally low blood pressure): 5 people, 19.23%
Fatigue (feeling of tiredness): 5 people, 19.23%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 4 people, 15.38%
Dyspnea Exertional: 4 people, 15.38%
Weight Increased: 4 people, 15.38%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 4 people, 15.38%

What are the existing conditions these people have? *

Cardiac Disorder: 5 people, 19.23%
Blood Pressure Abnormal: 3 people, 11.54%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 11.54%
Waldenstrom's Macroglobulinaemia (cancer affects small lymphocytes (white blood cells)): 2 people, 7.69%
Inflammation: 2 people, 7.69%
Heart Rate Irregular: 2 people, 7.69%
Urinary Tract Infection: 2 people, 7.69%
High Blood Pressure: 2 people, 7.69%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 2 people, 7.69%
Joint Swelling: 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Tikosyn and have Presyncope?

- Check whether Presyncope is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tikosyn:

Tikosyn (12,202 reports)

Presyncope treatments and more:

Presyncope (26,156 reports)

Browse all side effects of Tikosyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Presyncope:

Presyncope (1,358 drugs)

Browse all the conditions that are associated with Presyncope:

Presyncope (1,288 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dofetilide (the active ingredients of Tikosyn) and Tikosyn (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.