Tiotropium bromide and Hepatotoxicity - a phase IV clinical study of FDA data

Summary:

Hepatotoxicity is reported as a side effect among people who take Tiotropium bromide (tiotropium bromide), especially for people who are female, 50-59 old, also take Nasonex, and have Hypomania.

The phase IV clinical study analyzes which people have Hepatotoxicity when taking Tiotropium bromide. It is created by eHealthMe based on reports of 7,685 people who have side effects when taking Tiotropium bromide from the FDA, and is updated regularly.

What is Tiotropium bromide?

Tiotropium bromide has active ingredients of tiotropium bromide. eHealthMe is studying from 7,688 Tiotropium bromide users. Check the latest studies of Tiotropium bromide.

What is Hepatotoxicity?

Hepatotoxicity (chemical-driven liver damage) is found to be associated with 1,084 drugs and 1,252 conditions by eHealthMe. Check the latest studies of Hepatotoxicity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

7,685 people reported to have side effects when taking Tiotropium bromide.
Among them, 12 people (0.16%) have Hepatotoxicity.

Could Tiotropium bromide cause Hepatotoxicity?

Among these 12 people:

What is the gender of people who have Hepatotoxicity when taking Tiotropium bromide? *

female: 100 %
male: 0.0 %

What is the age of people who have Hepatotoxicity when taking Tiotropium bromide? *

What are other drugs people take besides Tiotropium bromide? *

Imodium: 5 people, 41.67%
Olanzapine: 5 people, 41.67%
Clonazepam: 5 people, 41.67%
Ciprofloxacin Hydrochloride: 5 people, 41.67%
Calcium Carbonate: 5 people, 41.67%
Breo Ellipta: 5 people, 41.67%
Kaletra: 5 people, 41.67%
Lactulose: 5 people, 41.67%
Lamivudine: 5 people, 41.67%
Nasonex: 5 people, 41.67%

What are other side effects people have besides Hepatotoxicity? *

Oedema Peripheral (superficial swelling): 7 people, 58.33%
Nausea And Vomiting: 7 people, 58.33%
Pneumonia: 7 people, 58.33%
Blood Bilirubin Increased: 7 people, 58.33%
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection): 5 people, 41.67%
Hepatic Enzyme Increased: 5 people, 41.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 41.67%
Gallstones (stone formation by bile component): 5 people, 41.67%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 41.67%
Nasal Polyps (masses that develop in the lining of the nose): 5 people, 41.67%

What are the existing conditions these people have? *

Depression: 4 people, 33.33%
Psychotic Disorder: 4 people, 33.33%
Hiv Infection: 4 people, 33.33%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 4 people, 33.33%
Hypomania (a mild form of mania, marked by elation and hyperactivity): 4 people, 33.33%
Type 2 Diabetes: 3 people, 25.00%
Urinary Tract Infection: 2 people, 16.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 16.67%
Diabetes: 2 people, 16.67%
High Blood Pressure: 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Tiotropium bromide and have Hepatotoxicity?

- Check whether Hepatotoxicity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tiotropium bromide:

Tiotropium bromide (7,688 reports)

Hepatotoxicity treatments and more:

Hepatotoxicity (23,823 reports)

Browse all side effects of Tiotropium bromide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatotoxicity:

Hepatotoxicity (1,084 drugs)

Browse all the conditions that are associated with Hepatotoxicity:

Hepatotoxicity (1,252 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tiotropium bromide (the active ingredients of Tiotropium bromide) and Tiotropium bromide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.