Tizanidine hydrochloride and Clonus - a phase IV clinical study of FDA data

Summary:

Clonus is reported as a side effect among people who take Tizanidine hydrochloride (tizanidine hydrochloride), especially for people who are female, 40-49 old, also take Ampyra, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Clonus when taking Tizanidine hydrochloride. It is created by eHealthMe based on reports of 6,179 people who have side effects when taking Tizanidine hydrochloride from the FDA, and is updated regularly.

What is Tizanidine hydrochloride?

Tizanidine hydrochloride has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 7,450 Tizanidine hydrochloride users. Check the latest studies of Tizanidine hydrochloride.

What is Clonus?

Clonus (series of involuntary, rhythmic, muscular contractions and relaxations) is found to be associated with 321 drugs and 559 conditions by eHealthMe. Check the latest studies of Clonus.

On Jan, 07, 2026

6,179 people reported to have side effects when taking Tizanidine hydrochloride.
Among them, 11 people (0.18%) have Clonus.

Could Tizanidine hydrochloride cause Clonus?

Among these 11 people:

What is the gender of people who have Clonus when taking Tizanidine hydrochloride? *

female: 60 %
male: 40 %

What is the age of people who have Clonus when taking Tizanidine hydrochloride? *

What are other drugs people take besides Tizanidine hydrochloride? *

What are other side effects people have besides Clonus? *

Fatigue (feeling of tiredness): 11 people, 100.00%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 10 people, 90.91%
Stress And Anxiety: 8 people, 72.73%
Pain In Extremity: 6 people, 54.55%
Ligament Rupture (tear in ligament): 6 people, 54.55%
Weight Decreased: 6 people, 54.55%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 54.55%
Dyskinesia (abnormality or impairment of voluntary movement): 6 people, 54.55%
Gait Disturbance: 6 people, 54.55%
Cartilage Injury: 6 people, 54.55%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 90.91%
Skin Blushing/flushing (a sudden reddening of the face, neck): 4 people, 36.36%
Seasonal Allergy (allergic condition due to certain season): 4 people, 36.36%
Hypersensitivity: 4 people, 36.36%
Gait Disturbance: 4 people, 36.36%
Depression: 4 people, 36.36%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 27.27%

* Approximation only. Some reports may have incomplete information.

Do you take Tizanidine hydrochloride and have Clonus?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tizanidine hydrochloride:

Tizanidine hydrochloride (7,450 reports)

Clonus treatments and more:

Clonus (3,236 reports)

Browse all side effects of Tizanidine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Clonus:

Clonus (321 drugs)

Browse all the conditions that are associated with Clonus:

Clonus (559 conditions)

Drugs similar to Tizanidine hydrochloride and Clonus :

How the study uses the data?

The study uses data from the FDA. It is based on tizanidine hydrochloride (the active ingredients of Tizanidine hydrochloride) and Tizanidine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.