Tofranil and Urinary retention - a phase IV clinical study of FDA data

Summary:

Urinary retention is reported as a side effect among people who take Tofranil (imipramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lioresal, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Urinary retention when taking Tofranil. It is created by eHealthMe based on reports of 1,933 people who have side effects when taking Tofranil from the FDA, and is updated regularly.

What is Tofranil?

Tofranil has active ingredients of imipramine hydrochloride. It is often used in depression. eHealthMe is studying from 2,012 Tofranil users. Check the latest studies of Tofranil.

What is Urinary retention?

Urinary retention (the inability to completely or partially empty the bladder) is found to be associated with 1,570 drugs and 1,737 conditions by eHealthMe. Check the latest studies of Urinary retention.

On Jul, 10, 2026

1,933 people reported to have side effects when taking Tofranil.
Among them, 13 people (0.67%) have Urinary retention.

Among these 13 people:

How long have people been on Tofranil when they have Urinary retention? *

What is the gender of people who have Urinary retention when taking Tofranil? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Urinary retention when taking Tofranil? *

What are other drugs people take besides Tofranil? *

What are other side effects people have besides Urinary retention? *

Confusional State: 3 people, 23.08%
Fall: 3 people, 23.08%
Rashes (redness): 3 people, 23.08%
Hepatic Function Abnormal: 2 people, 15.38%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 2 people, 15.38%
Arrhythmias (irregular heartbeat): 2 people, 15.38%
Bladder Distension: 2 people, 15.38%
Blood Pressure Systolic Increased: 2 people, 15.38%
Delirium (wild excitement): 2 people, 15.38%
Diabetes Mellitus Inadequate Control: 2 people, 15.38%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 23.08%
Urinary Tract Infection: 1 person, 7.69%
Uraemic Acidosis (acidosis caused by excess nitrogenous waste products in the urine): 1 person, 7.69%
Spinal Osteoarthritis (joint cartilage loss in spine): 1 person, 7.69%
Micturition Urgency (urgency to pass the urine): 1 person, 7.69%
Insomnia (sleeplessness): 1 person, 7.69%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 1 person, 7.69%
High Blood Pressure: 1 person, 7.69%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 1 person, 7.69%
Constipation: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Tofranil and have Urinary retention?

- Check whether Urinary retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tofranil:

Tofranil (2,012 reports)

Browse all side effects of Tofranil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Urinary retention:

Urinary retention (1,570 drugs)

Browse all the conditions that are associated with Urinary retention:

Urinary retention (1,737 conditions)

Related publications that referenced our studies

Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .

How the study uses the data?

The study uses data from the FDA. It is based on imipramine hydrochloride (the active ingredients of Tofranil) and Tofranil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.