Tolvaptan and Ventricular fibrillation - a phase IV clinical study of FDA data

Summary:

Ventricular fibrillation is reported as a side effect among people who take Tolvaptan (tolvaptan), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Samsca, and have Cardiac failure.

The phase IV clinical study analyzes which people have Ventricular fibrillation when taking Tolvaptan. It is created by eHealthMe based on reports of 5,682 people who have side effects when taking Tolvaptan from the FDA, and is updated regularly.

What is Tolvaptan?

Tolvaptan has active ingredients of tolvaptan. eHealthMe is studying from 5,685 Tolvaptan users. Check the latest studies of Tolvaptan.

What is Ventricular fibrillation?

Ventricular fibrillation (abnormally irregular heart rhythm) is found to be associated with 1,092 drugs and 1,246 conditions by eHealthMe. Check the latest studies of Ventricular fibrillation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

5,682 people reported to have side effects when taking Tolvaptan.
Among them, 11 people (0.19%) have Ventricular fibrillation.

Could Tolvaptan cause Ventricular fibrillation?

Among these 11 people:

How long have people been on Tolvaptan when they have Ventricular fibrillation? *

What is the gender of people who have Ventricular fibrillation when taking Tolvaptan? *

female: 40 %
male: 60 %

What is the age of people who have Ventricular fibrillation when taking Tolvaptan? *

What are other drugs people take besides Tolvaptan? *

Samsca: 4 people, 36.36%
Furosemide: 3 people, 27.27%
Lasix: 3 people, 27.27%
Spironolactone: 2 people, 18.18%
Amiodarone Hydrochloride: 2 people, 18.18%
Bisoprolol Fumarate: 2 people, 18.18%
Dexamethasone Sodium Phosphate: 2 people, 18.18%
Amlodipine: 1 person, 9.09%
Aspirin: 1 person, 9.09%
Coreg: 1 person, 9.09%

What are other side effects people have besides Ventricular fibrillation? *

Hypokalemia (low potassium): 5 people, 45.45%
Hyperkalemia (damage to or disease of the kidney): 3 people, 27.27%
Cardiac Arrest: 3 people, 27.27%
Hypernatraemia (an abnormally high plasma concentration of sodium ions): 3 people, 27.27%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 2 people, 18.18%
Electrocardiogram Qt Prolonged: 2 people, 18.18%
Photopsia (presence of perceived flashes of light): 2 people, 18.18%
Blood Pressure Systolic Increased: 1 person, 9.09%
Cardiac Failure: 1 person, 9.09%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 9.09%

What are the existing conditions these people have? *

Cardiac Failure Congestive: 4 people, 36.36%
Cardiac Failure: 4 people, 36.36%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 27.27%
Cardiac Failure Chronic: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Tolvaptan and have Ventricular fibrillation?

- Check whether Ventricular fibrillation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tolvaptan:

Tolvaptan (5,685 reports)

Browse all side effects of Tolvaptan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ventricular fibrillation:

Ventricular fibrillation (1,092 drugs)

Browse all the conditions that are associated with Ventricular fibrillation:

Ventricular fibrillation (1,246 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tolvaptan (the active ingredients of Tolvaptan) and Tolvaptan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.