Topiramate and Hyperchloraemia - a phase IV clinical study of FDA data

Summary:

Hyperchloraemia is reported as a side effect among people who take Topiramate (topiramate), especially for people who are male, 10-19 old, have been taking the drug for < 1 month also take Levetiracetam, and have Seizures.

The phase IV clinical study analyzes which people have Hyperchloraemia when taking Topiramate. It is created by eHealthMe based on reports of 48,099 people who have side effects when taking Topiramate from the FDA, and is updated regularly.

What is Topiramate?

Topiramate has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 49,809 Topiramate users. Check the latest studies of Topiramate.

What is Hyperchloraemia?

Hyperchloraemia (an excess of chlorides in the blood) is found to be associated with 112 drugs and 171 conditions by eHealthMe. Check the latest studies of Hyperchloraemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

48,099 people reported to have side effects when taking Topiramate.
Among them, 31 people (0.06%) have Hyperchloraemia.

Among these 31 people:

How long have people been on Topiramate when they have Hyperchloraemia? *

What is the gender of people who have Hyperchloraemia when taking Topiramate? *

female: 37.04 %
male: 62.96 %

What is the age of people who have Hyperchloraemia when taking Topiramate? *

What are other drugs people take besides Topiramate? *

What are other side effects people have besides Hyperchloraemia? *

Hypernatraemia (an abnormally high plasma concentration of sodium ions): 14 people, 45.16%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 14 people, 45.16%
Hypotonia (low muscle tone): 13 people, 41.94%
Hypokalemia (low potassium): 11 people, 35.48%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 9 people, 29.03%
Sopor (sleep): 9 people, 29.03%
Drowsiness: 8 people, 25.81%
Bradycardia (abnormally slow heart action): 6 people, 19.35%
Bundle Branch Block Right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle): 6 people, 19.35%
Cardiac Arrest: 6 people, 19.35%

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 16.13%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 4 people, 12.90%
Suicide Attempt: 2 people, 6.45%
Skin Discoloration: 1 person, 3.23%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 3.23%
Partial Seizures (seizures which affect only a part of the brain at onset): 1 person, 3.23%
Dyskinesia (abnormality or impairment of voluntary movement): 1 person, 3.23%
Dementia (madness): 1 person, 3.23%
Affective Disorder (mental disorder): 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Topiramate and have Hyperchloraemia?

- Check whether Hyperchloraemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Topiramate:

Topiramate (49,809 reports)

Browse all side effects of Topiramate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperchloraemia:

Hyperchloraemia (112 drugs)

Browse all the conditions that are associated with Hyperchloraemia:

Hyperchloraemia (171 conditions)

Related publications that referenced our studies

Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .
Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on topiramate (the active ingredients of Topiramate) and Topiramate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.