Topiramate and Immune reconstitution syndrome - a phase IV clinical study of FDA data

Summary:

Immune reconstitution syndrome is reported as a side effect among people who take Topiramate (topiramate), especially for people who are female, 40-49 old, also take Aspirin, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Immune reconstitution syndrome when taking Topiramate. It is created by eHealthMe based on reports of 48,099 people who have side effects when taking Topiramate from the FDA, and is updated regularly.

What is Topiramate?

Topiramate has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 49,809 Topiramate users. Check the latest studies of Topiramate.

What is Immune reconstitution syndrome?

Immune reconstitution syndrome (immune recovery syndrome) is found to be associated with 207 drugs and 394 conditions by eHealthMe. Check the latest studies of Immune reconstitution syndrome.

On Jul, 07, 2026

48,099 people reported to have side effects when taking Topiramate.
Among them, 11 people (0.02%) have Immune reconstitution syndrome.

Could Topiramate cause Immune reconstitution syndrome?

Among these 11 people:

What is the gender of people who have Immune reconstitution syndrome when taking Topiramate? *

female: 63.64 %
male: 36.36 %

What is the age of people who have Immune reconstitution syndrome when taking Topiramate? *

What are other drugs people take besides Topiramate? *

What are other side effects people have besides Immune reconstitution syndrome? *

Progressive Multifocal Leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells): 10 people, 90.91%
White Blood Cell Count Decreased: 1 person, 9.09%
Heart Rate Decreased: 1 person, 9.09%
Balance Disorder: 1 person, 9.09%
Bone Marrow Toxicity (decrease in cells responsible for providing immunity, carrying oxygen, and those responsible for normal blood clotting): 1 person, 9.09%
Cytomegalovirus Antibody Positive: 1 person, 9.09%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 1 person, 9.09%
Drowsiness: 1 person, 9.09%
Drug Resistance (reduction in effectiveness of a drug): 1 person, 9.09%
Epidermal Necrosis (skin condition that is usually caused by a reaction to drugs): 1 person, 9.09%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 63.64%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 3 people, 27.27%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 27.27%
Hiv Infection: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Topiramate and have Immune reconstitution syndrome?

- Check whether Immune reconstitution syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Topiramate:

Topiramate (49,809 reports)

Browse all side effects of Topiramate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Immune reconstitution syndrome:

Immune reconstitution syndrome (207 drugs)

Browse all the conditions that are associated with Immune reconstitution syndrome:

Immune reconstitution syndrome (394 conditions)

Related publications that referenced our studies

Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .
Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on topiramate (the active ingredients of Topiramate) and Topiramate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.