Topiramate and Inappropriate affect - a phase IV clinical study of FDA data

Summary:

Inappropriate affect is reported as a side effect among people who take Topiramate (topiramate), especially for people who are female, 2-9 old, have been taking the drug for < 1 month also take Zopiclone, and have Depression.

The phase IV clinical study analyzes which people have Inappropriate affect when taking Topiramate. It is created by eHealthMe based on reports of 48,099 people who have side effects when taking Topiramate from the FDA, and is updated regularly.

What is Topiramate?

Topiramate has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 49,809 Topiramate users. Check the latest studies of Topiramate.

What is Inappropriate affect?

Inappropriate affect is found to be associated with 255 drugs and 385 conditions by eHealthMe. Check the latest studies of Inappropriate affect.

On Aug, 02, 2026

48,099 people reported to have side effects when taking Topiramate.
Among them, 26 people (0.05%) have Inappropriate affect.

Could Topiramate cause Inappropriate affect?

Among these 26 people:

How long have people been on Topiramate when they have Inappropriate affect? *

What is the gender of people who have Inappropriate affect when taking Topiramate? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Inappropriate affect when taking Topiramate? *

What are other drugs people take besides Topiramate? *

Keppra: 6 people, 23.08%
Metformin: 6 people, 23.08%
Zopiclone: 6 people, 23.08%
Escitalopram: 4 people, 15.38%
Eliquis: 4 people, 15.38%
Valacyclovir: 4 people, 15.38%
Namenda: 4 people, 15.38%
Nuplazid: 4 people, 15.38%
Carbidopa And Levodopa: 4 people, 15.38%
Levetiracetam: 3 people, 11.54%

What are other side effects people have besides Inappropriate affect? *

Insomnia (sleeplessness): 9 people, 34.62%
Agitation (state of anxiety or nervous excitement): 9 people, 34.62%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 7 people, 26.92%
Affect Lability (emotional incontinence): 7 people, 26.92%
Panic Disorder: 6 people, 23.08%
Hallucination, Visual (seeing things that aren't there): 6 people, 23.08%
Psychomotor Hyperactivity (feelings of extreme restlessness): 5 people, 19.23%
Neuralgia (pain in one or more nerves): 4 people, 15.38%
Sleep Disorder: 4 people, 15.38%
Irritability: 4 people, 15.38%

What are the existing conditions these people have? *

Depression: 7 people, 26.92%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 23.08%
Insomnia (sleeplessness): 6 people, 23.08%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 4 people, 15.38%
Parkinson's Disease: 4 people, 15.38%
Hallucinations (sensations that appear real but are created by your mind): 4 people, 15.38%
Encephalopathy (functioning of the brain is affected by some agent or condition): 3 people, 11.54%
Psychotic Disorder Due To A General Medical Condition: 3 people, 11.54%
Abnormal Weight Gain: 2 people, 7.69%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Topiramate and have Inappropriate affect?

- Check whether Inappropriate affect is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Topiramate:

Topiramate (49,809 reports)

Browse all side effects of Topiramate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Inappropriate affect:

Inappropriate affect (255 drugs)

Browse all the conditions that are associated with Inappropriate affect:

Inappropriate affect (385 conditions)

Related publications that referenced our studies

Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .
Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on topiramate (the active ingredients of Topiramate) and Topiramate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.