Topotecan and Arrhythmias - a phase IV clinical study of FDA data

Summary:

Arrhythmias is reported as a side effect among people who take Topotecan (topotecan hydrochloride), especially for people who are female, 2-9 old, have been taking the drug for < 1 month also take Cyclophosphamide, and have Nausea.

The phase IV clinical study analyzes which people have Arrhythmias when taking Topotecan. It is created by eHealthMe based on reports of 5,841 people who have side effects when taking Topotecan from the FDA, and is updated regularly.

What is Topotecan?

Topotecan has active ingredients of topotecan hydrochloride. eHealthMe is studying from 5,853 Topotecan users. Check the latest studies of Topotecan.

What is Arrhythmias?

Arrhythmias (irregular heartbeat) is found to be associated with 2,755 drugs and 4,840 conditions by eHealthMe. Check the latest studies of Arrhythmias.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

5,841 people reported to have side effects when taking Topotecan.
Among them, 76 people (1.3%) have Arrhythmias.

Among these 76 people:

How long have people been on Topotecan when they have Arrhythmias? *

What is the gender of people who have Arrhythmias when taking Topotecan? *

female: 73.13 %
male: 26.87 %

What is the age of people who have Arrhythmias when taking Topotecan? *

What are other drugs people take besides Topotecan? *

Cyclophosphamide: 21 people, 27.63%
Ondansetron: 10 people, 13.16%
Cisplatin: 9 people, 11.84%
Acetaminophen: 8 people, 10.53%
Pantoprazole: 7 people, 9.21%
Zofran: 7 people, 9.21%
Morphine: 5 people, 6.58%
Lasix: 5 people, 6.58%
Lansoprazole: 5 people, 6.58%
Irinotecan Hydrochloride: 5 people, 6.58%

What are other side effects people have besides Arrhythmias? *

Fever: 25 people, 32.89%
Hypotension (abnormally low blood pressure): 21 people, 27.63%
Nausea And Vomiting: 20 people, 26.32%
Fatigue (feeling of tiredness): 18 people, 23.68%
Anaemia (lack of blood): 17 people, 22.37%
Dyspnea (difficult or laboured breathing): 15 people, 19.74%
Diarrhea: 14 people, 18.42%
Nausea (feeling of having an urge to vomit): 14 people, 18.42%
Thrombocytopenia (decrease of platelets in blood): 13 people, 17.11%
Dehydration (dryness resulting from the removal of water): 13 people, 17.11%

What are the existing conditions these people have? *

Refractory Cancer (cancer that has not responded to treatment): 6 people, 7.89%
Recurrent Cancer (repeated cancer): 6 people, 7.89%
Nausea (feeling of having an urge to vomit): 6 people, 7.89%
Nausea And Vomiting: 5 people, 6.58%
Constipation: 5 people, 6.58%
Fever: 5 people, 6.58%
Cervix Carcinoma (cancer of cervix): 5 people, 6.58%
Pain: 5 people, 6.58%
Eye Infection: 4 people, 5.26%
Bone Disorder: 4 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Topotecan and have Arrhythmias?

- Check whether Arrhythmias is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Topotecan:

Topotecan (5,853 reports)

Arrhythmias treatments and more:

Arrhythmias (177,909 reports)

Browse all side effects of Topotecan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Arrhythmias:

Arrhythmias (2,755 drugs)

Browse all the conditions that are associated with Arrhythmias:

Arrhythmias (4,840 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on topotecan hydrochloride (the active ingredients of Topotecan) and Topotecan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.