Topotecan and Small intestinal obstruction - a phase IV clinical study of FDA data

Summary:

Small intestinal obstruction is reported as a side effect among people who take Topotecan (topotecan hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Nicotine, and have Ovarian cancer.

The phase IV clinical study analyzes which people have Small intestinal obstruction when taking Topotecan. It is created by eHealthMe based on reports of 5,841 people who have side effects when taking Topotecan from the FDA, and is updated regularly.

What is Topotecan?

Topotecan has active ingredients of topotecan hydrochloride. eHealthMe is studying from 5,853 Topotecan users. Check the latest studies of Topotecan.

What is Small intestinal obstruction?

Small intestinal obstruction (blockage in small intestine) is found to be associated with 1,035 drugs and 986 conditions by eHealthMe. Check the latest studies of Small intestinal obstruction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

5,841 people reported to have side effects when taking Topotecan.
Among them, 23 people (0.39%) have Small intestinal obstruction.

Could Topotecan cause Small intestinal obstruction?

Among these 23 people:

How long have people been on Topotecan when they have Small intestinal obstruction? *

What is the gender of people who have Small intestinal obstruction when taking Topotecan? *

female: 90 %
male: 10 %

What is the age of people who have Small intestinal obstruction when taking Topotecan? *

What are other drugs people take besides Topotecan? *

What are other side effects people have besides Small intestinal obstruction? *

Nausea (feeling of having an urge to vomit): 7 people, 30.43%
Abdominal Pain: 6 people, 26.09%
Nausea And Vomiting: 6 people, 26.09%
Unilateral Hydronephrosis (kidney stone that causes obstruction of the ureter): 3 people, 13.04%
Hypotension (abnormally low blood pressure): 3 people, 13.04%
Fatigue (feeling of tiredness): 3 people, 13.04%
Abdominal Distension: 2 people, 8.70%
Pain: 2 people, 8.70%
Weakness: 2 people, 8.70%
Flatulence (flatus expelled through the anus): 2 people, 8.70%

What are the existing conditions these people have? *

Ovarian Cancer (cancer of ovary): 4 people, 17.39%
Stress And Anxiety: 1 person, 4.35%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 4.35%
Rashes (redness): 1 person, 4.35%
Pain: 1 person, 4.35%
Ovarian Epithelial Cancer (cancer that begins in the cells on the surface of the ovary): 1 person, 4.35%
Ovarian Cancer Recurrent (reoccurrence of ovary cancer): 1 person, 4.35%
Nausea And Vomiting: 1 person, 4.35%
Nausea (feeling of having an urge to vomit): 1 person, 4.35%
Malignant Peritoneal Neoplasm (cancer tumour of peritoneum): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Topotecan and have Small intestinal obstruction?

- Check whether Small intestinal obstruction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Topotecan:

Topotecan (5,853 reports)

Browse all side effects of Topotecan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Small intestinal obstruction:

Small intestinal obstruction (1,035 drugs)

Browse all the conditions that are associated with Small intestinal obstruction:

Small intestinal obstruction (986 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on topotecan hydrochloride (the active ingredients of Topotecan) and Topotecan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.