Toprol-xl and Schizophrenia - a phase IV clinical study of FDA data

Summary:

Schizophrenia is reported as a side effect among people who take Toprol-xl (metoprolol succinate), especially for people who are male, 50-59 old, also take Seroquel, and have Pain.

The phase IV clinical study analyzes which people have Schizophrenia when taking Toprol-xl. It is created by eHealthMe based on reports of 38,273 people who have side effects when taking Toprol-xl from the FDA, and is updated regularly.

What is Toprol-xl?

Toprol-xl has active ingredients of metoprolol succinate. It is often used in high blood pressure. eHealthMe is studying from 40,636 Toprol-xl users. Check the latest studies of Toprol-xl.

What is Schizophrenia?

Schizophrenia (a mental disorder characterized by a breakdown of thought processes) is found to be associated with 512 drugs and 725 conditions by eHealthMe. Check the latest studies of Schizophrenia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

38,273 people reported to have side effects when taking Toprol-xl.
Among them, 14 people (0.04%) have Schizophrenia.

Among these 14 people:

What is the gender of people who have Schizophrenia when taking Toprol-xl? *

female: 14.29 %
male: 85.71 %

What is the age of people who have Schizophrenia when taking Toprol-xl? *

What are other drugs people take besides Toprol-xl? *

What are other side effects people have besides Schizophrenia? *

Bipolar Disorder (mood disorder): 5 people, 35.71%
Psychotic Disorder: 4 people, 28.57%
Headache (pain in head): 4 people, 28.57%
Pancreatitis (inflammation of pancreas): 4 people, 28.57%
Chest Pain: 4 people, 28.57%
Insomnia (sleeplessness): 3 people, 21.43%
Back Pain: 3 people, 21.43%
Stress And Anxiety: 3 people, 21.43%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 3 people, 21.43%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 3 people, 21.43%

What are the existing conditions these people have? *

Pain: 5 people, 35.71%
Stress And Anxiety: 2 people, 14.29%
Rashes (redness): 2 people, 14.29%
Prostate Cancer: 2 people, 14.29%
Panic Disorder: 2 people, 14.29%
Nausea (feeling of having an urge to vomit): 2 people, 14.29%
Multiple Allergies (allergy to multiple agents): 2 people, 14.29%
High Blood Cholesterol: 2 people, 14.29%
Gastric Ulcer (stomach ulcer): 2 people, 14.29%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Toprol-xl and have Schizophrenia?

- Check whether Schizophrenia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Toprol-xl:

Toprol-xl (40,636 reports)

Schizophrenia treatments and more:

Schizophrenia (130,798 reports)

Browse all side effects of Toprol-xl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Schizophrenia:

Schizophrenia (512 drugs)

Browse all the conditions that are associated with Schizophrenia:

Schizophrenia (725 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metoprolol succinate (the active ingredients of Toprol-xl) and Toprol-xl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.