Toviaz and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Toviaz (fesoterodine fumarate), especially for people who are female, 60+ old, also take Celebrex, and have Depression.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Toviaz. It is created by eHealthMe based on reports of 13,173 people who have side effects when taking Toviaz from the FDA, and is updated regularly.

What is Toviaz?

Toviaz has active ingredients of fesoterodine fumarate. It is often used in urge incontinence. eHealthMe is studying from 13,353 Toviaz users. Check the latest studies of Toviaz.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 946 drugs and 1,232 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

13,173 people reported to have side effects when taking Toviaz.
Among them, 17 people (0.13%) have Knee joint replacement.

Could Toviaz cause Knee joint replacement?

Among these 17 people:

What is the gender of people who have Knee joint replacement when taking Toviaz? *

female: 100 %
male: 0.0 %

What is the age of people who have Knee joint replacement when taking Toviaz? *

What are other drugs people take besides Toviaz? *

What are other side effects people have besides Knee joint replacement? *

Pain: 5 people, 29.41%
Stress And Anxiety: 5 people, 29.41%
Osteoporosis (bones weak and more likely to break): 3 people, 17.65%
Arthropathy: 3 people, 17.65%
Procedural Pain: 3 people, 17.65%
Drug Ineffective: 3 people, 17.65%
Drowsiness: 2 people, 11.76%
Memory Loss: 2 people, 11.76%
Ligament Rupture (tear in ligament): 2 people, 11.76%
Joint Pain: 2 people, 11.76%

What are the existing conditions these people have? *

High Blood Cholesterol: 3 people, 17.65%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 17.65%
Depression: 3 people, 17.65%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 11.76%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 11.76%
Hypersensitivity: 2 people, 11.76%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 11.76%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 11.76%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 11.76%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Toviaz and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Toviaz:

Toviaz (13,353 reports)

Browse all side effects of Toviaz:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (946 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,232 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fesoterodine fumarate (the active ingredients of Toviaz) and Toviaz (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.