Tpn and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Tpn (niacinamide; pyridoxine hydrochloride; tyrosine), especially for people who are female, 60+ old, also take Aspirin, and have Short-bowel syndrome.

The phase IV clinical study analyzes which people have Depression when taking Tpn. It is created by eHealthMe based on reports of 1,568 people who have side effects when taking Tpn from the FDA, and is updated regularly.

What is Tpn?

Tpn has active ingredients of niacinamide; pyridoxine hydrochloride; tyrosine. eHealthMe is studying from 1,581 Tpn users. Check the latest studies of Tpn.

What is Depression?

Depression is found to be associated with 3,167 drugs and 4,125 conditions by eHealthMe. Check the latest studies of Depression.

On Jul, 15, 2026

1,568 people reported to have side effects when taking Tpn.
Among them, 23 people (1.47%) have Depression.

Among these 23 people:

What is the gender of people who have Depression when taking Tpn? *

female: 77.27 %
male: 22.73 %

What is the age of people who have Depression when taking Tpn? *

What are other drugs people take besides Tpn? *

What are other side effects people have besides Depression? *

Weight Decreased: 17 people, 73.91%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 13 people, 56.52%
Fatigue (feeling of tiredness): 11 people, 47.83%
Abdominal Distension: 10 people, 43.48%
Diarrhea: 10 people, 43.48%
Pain: 9 people, 39.13%
Nausea And Vomiting: 8 people, 34.78%
Nausea (feeling of having an urge to vomit): 7 people, 30.43%
High Blood Pressure: 6 people, 26.09%
Dehydration (dryness resulting from the removal of water): 6 people, 26.09%

What are the existing conditions these people have? *

Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 18 people, 78.26%
Dehydration (dryness resulting from the removal of water): 5 people, 21.74%
Vitamin D Decreased: 4 people, 17.39%
High Blood Pressure: 4 people, 17.39%
Blood Pressure Abnormal: 3 people, 13.04%
Diarrhea: 3 people, 13.04%
Abdominal Discomfort: 3 people, 13.04%
Stress And Anxiety: 3 people, 13.04%
Neuropathy Peripheral (surface nerve damage): 2 people, 8.70%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Tpn and have Depression?

- Check whether Depression is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tpn:

Tpn (1,581 reports)

Depression treatments and more:

Depression (652,144 reports)

How severe was Depression and when was it recovered:

Depression in Tpn

Expand to all the drugs that have ingredients of niacinamide; pyridoxine hydrochloride; tyrosine:

Depression and drugs with ingredients of niacinamide; pyridoxine hydrochloride; tyrosine (22 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tpn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,167 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,125 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on niacinamide; pyridoxine hydrochloride; tyrosine (the active ingredients of Tpn) and Tpn (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.