Tramadol hydrochloride and Formication - a phase IV clinical study of FDA data

Summary:

Formication is reported as a side effect among people who take Tramadol hydrochloride (tramadol hydrochloride), especially for people who are male, 20-29 old, have been taking the drug for 2 - 5 years also take Lyrica, and have Epilepsy.

The phase IV clinical study analyzes which people have Formication when taking Tramadol hydrochloride. It is created by eHealthMe based on reports of 38,309 people who have side effects when taking Tramadol hydrochloride from the FDA, and is updated regularly.

What is Tramadol hydrochloride?

Tramadol hydrochloride has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 40,749 Tramadol hydrochloride users. Check the latest studies of Tramadol hydrochloride.

What is Formication?

Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin) is found to be associated with 553 drugs and 918 conditions by eHealthMe. Check the latest studies of Formication.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

38,309 people reported to have side effects when taking Tramadol hydrochloride.
Among them, 16 people (0.04%) have Formication.

Could Tramadol hydrochloride cause Formication?

Among these 16 people:

How long have people been on Tramadol hydrochloride when they have Formication? *

What is the gender of people who have Formication when taking Tramadol hydrochloride? *

female: 43.75 %
male: 56.25 %

What is the age of people who have Formication when taking Tramadol hydrochloride? *

What are other drugs people take besides Tramadol hydrochloride? *

What are other side effects people have besides Formication? *

Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 5 people, 31.25%
Overdose: 4 people, 25.00%
Agitation (state of anxiety or nervous excitement): 4 people, 25.00%
Fatigue (feeling of tiredness): 3 people, 18.75%
Euphoric Mood (excessively happy but may become angry or irritable): 3 people, 18.75%
Insomnia (sleeplessness): 3 people, 18.75%
Drug Ineffective: 3 people, 18.75%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 18.75%
Stress And Anxiety: 3 people, 18.75%
Weakness: 2 people, 12.50%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.25%
Pelvic Pain: 1 person, 6.25%
Neuropathy Peripheral (surface nerve damage): 1 person, 6.25%
Neuralgia (pain in one or more nerves): 1 person, 6.25%
Nervousness: 1 person, 6.25%
Neck Pain: 1 person, 6.25%
Muscle Aches (muscle pain): 1 person, 6.25%
Insomnia (sleeplessness): 1 person, 6.25%
Headache (pain in head): 1 person, 6.25%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Tramadol hydrochloride and have Formication?

- Check whether Formication is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tramadol hydrochloride:

Tramadol hydrochloride (40,749 reports)

Formication treatments and more:

Formication (8,246 reports)

Browse all side effects of Tramadol hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Formication:

Formication (553 drugs)

Browse all the conditions that are associated with Formication:

Formication (918 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Tramadol hydrochloride) and Tramadol hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.