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Tramadol and Bladder transitional cell carcinoma - a phase IV clinical study of FDA data

Summary:

Bladder transitional cell carcinoma is reported as a side effect among people who take Tramadol (tramadol hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Omeprazole, and have Metastases to bone.

The phase IV clinical study analyzes which people have Bladder transitional cell carcinoma when taking Tramadol. It is created by eHealthMe based on reports of 229,782 people who have side effects when taking Tramadol from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Bladder transitional cell carcinoma?

Bladder transitional cell carcinoma (types of bladder cancer) is found to be associated with 200 drugs and 229 conditions by eHealthMe. Check the latest studies of Bladder transitional cell carcinoma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

229,782 people reported to have side effects when taking Tramadol.
Among them, 28 people (0.01%) have Bladder transitional cell carcinoma.

Could Tramadol cause Bladder transitional cell carcinoma?

Among these 28 people:

How long have people been on Tramadol when they have Bladder transitional cell carcinoma? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 100 %
  • 10+ years: 0.0 %

What is the gender of people who have Bladder transitional cell carcinoma when taking Tramadol? *

  • female: 80 %
  • male: 20 %

What is the age of people who have Bladder transitional cell carcinoma when taking Tramadol? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 4 %
  • 30-39: 0.0 %
  • 40-49: 12 %
  • 50-59: 4 %
  • 60+: 80 %

What are other drugs people take besides Tramadol? *

  1. Benadryl: 13 people, 46.43%
  2. Omeprazole: 13 people, 46.43%
  3. Lortab: 12 people, 42.86%
  4. Fosamax: 12 people, 42.86%
  5. Flexeril: 12 people, 42.86%
  6. Aspirin: 11 people, 39.29%
  7. Vicodin: 10 people, 35.71%
  8. Metoclopramide: 10 people, 35.71%
  9. Neurontin: 10 people, 35.71%
  10. Oxycontin: 10 people, 35.71%

What are other side effects people have besides Bladder transitional cell carcinoma? *

  1. Haematuria (presence of blood in urine): 12 people, 42.86%
  2. Weakness: 11 people, 39.29%
  3. Stress And Anxiety: 11 people, 39.29%
  4. Spinal Osteoarthritis (joint cartilage loss in spine): 10 people, 35.71%
  5. Periodontitis (inflammation of the tissue around the teeth): 10 people, 35.71%
  6. Primary Sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone): 10 people, 35.71%
  7. Osteoporosis (bones weak and more likely to break): 10 people, 35.71%
  8. Gastrointestinal Disorder (functional problems of gastrointestinal tract): 10 people, 35.71%
  9. Pulmonary Mass: 10 people, 35.71%
  10. Gallstones (stone formation by bile component): 10 people, 35.71%

What are the existing conditions these people have? *

  1. Stress And Anxiety: 9 people, 32.14%
  2. Metastases To Bone (cancer spreads to bone): 9 people, 32.14%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 14.29%
  4. Renal Disorder (kidney disease): 4 people, 14.29%
  5. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 10.71%
  6. Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 3 people, 10.71%
  7. Multiple Myeloma (cancer of the plasma cells): 3 people, 10.71%
  8. Type 2 Diabetes: 2 people, 7.14%
  9. Bone Disorder: 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Tramadol and have Bladder transitional cell carcinoma?

- Check whether Bladder transitional cell carcinoma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tramadol:

Bladder transitional cell carcinoma treatments and more:

How severe was Bladder transitional cell carcinoma and when was it recovered:

Expand to all the drugs that have ingredients of tramadol hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bladder transitional cell carcinoma:

Browse all the conditions that are associated with Bladder transitional cell carcinoma:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Tramadol) and Tramadol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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