Tramadol and Bowel movement irregularity - a phase IV clinical study of FDA data

Summary:

Bowel movement irregularity is reported as a side effect among people who take Tramadol (tramadol hydrochloride), especially for people who are female, 60+ old, also take Vitamin D3, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Bowel movement irregularity when taking Tramadol. It is created by eHealthMe based on reports of 229,782 people who have side effects when taking Tramadol from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Bowel movement irregularity?

Bowel movement irregularity is found to be associated with 692 drugs and 629 conditions by eHealthMe. Check the latest studies of Bowel movement irregularity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

229,782 people reported to have side effects when taking Tramadol.
Among them, 124 people (0.05%) have Bowel movement irregularity.

Could Tramadol cause Bowel movement irregularity?

Among these 124 people:

What is the gender of people who have Bowel movement irregularity when taking Tramadol? *

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What is the age of people who have Bowel movement irregularity when taking Tramadol? *

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* Approximation only. Some reports may have incomplete information.

Do you take Tramadol and have Bowel movement irregularity?

- Check whether Bowel movement irregularity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tramadol:

Tramadol (235,800 reports)

Bowel movement irregularity treatments and more:

Bowel movement irregularity (11,012 reports)

How severe was Bowel movement irregularity and when was it recovered:

Bowel movement irregularity in Tramadol

Expand to all the drugs that have ingredients of tramadol hydrochloride:

Bowel movement irregularity and drugs with ingredients of tramadol hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bowel movement irregularity:

Bowel movement irregularity (692 drugs)

Browse all the conditions that are associated with Bowel movement irregularity:

Bowel movement irregularity (629 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Tramadol) and Tramadol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.