Tramadol and Cell death - a phase IV clinical study of FDA data

Summary:

Cell death is reported as a side effect among people who take Tramadol (tramadol hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Acetaminophen, and have Headache.

The study is created by eHealthMe based on reports of 229,782 people who have side effects when taking Tramadol from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

On Aug, 11, 2026

229,782 people reported to have side effects when taking Tramadol.
Among them, 55 people (0.02%) died.

Among these 55 people:

How long have people been on Tramadol when they died? *

What is the gender of people who died when taking Tramadol? *

female: 53.06 %
male: 46.94 %

What is the age of people who died when taking Tramadol? *

What are other drugs people take besides Tramadol? *

What are other side effects people have before they died? *

Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 27 people, 49.09%
Acute Kidney Failure: 20 people, 36.36%
Hepatic Failure (liver failure): 18 people, 32.73%
Thrombocytopenia (decrease of platelets in blood): 18 people, 32.73%
Hypoglycemia (low blood sugar): 17 people, 30.91%
Lactic Acidosis (low ph in body tissues): 14 people, 25.45%
Overdose: 13 people, 23.64%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 13 people, 23.64%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 12 people, 21.82%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 12 people, 21.82%

What are the existing conditions these people have? *

Headache (pain in head): 10 people, 18.18%
Insomnia (sleeplessness): 7 people, 12.73%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 6 people, 10.91%
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases): 6 people, 10.91%
Cardiac Failure: 6 people, 10.91%
Nausea (feeling of having an urge to vomit): 6 people, 10.91%
High Blood Pressure: 6 people, 10.91%
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble): 6 people, 10.91%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 6 people, 10.91%
High Blood Cholesterol: 4 people, 7.27%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tramadol:

Tramadol (235,800 reports)

Expand to all the drugs that have ingredients of tramadol hydrochloride:

Cell death and drugs with ingredients of tramadol hydrochloride (58 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cell death:

Cell death (210 drugs)

Browse all the conditions that are associated with Cell death:

Cell death (331 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Tramadol) and Tramadol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.