Tramadol and Connective tissue disorder - a phase IV clinical study of FDA data

Summary:

Connective tissue disorder is reported as a side effect among people who take Tramadol (tramadol hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Lyrica, and have Arrhythmias.

The phase IV clinical study analyzes which people have Connective tissue disorder when taking Tramadol. It is created by eHealthMe based on reports of 229,782 people who have side effects when taking Tramadol from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Connective tissue disorder?

Connective tissue disorder (any disease that has the connective tissues of the body) is found to be associated with 280 drugs and 389 conditions by eHealthMe. Check the latest studies of Connective tissue disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

229,782 people reported to have side effects when taking Tramadol.
Among them, 48 people (0.02%) have Connective tissue disorder.

Could Tramadol cause Connective tissue disorder?

Among these 48 people:

How long have people been on Tramadol when they have Connective tissue disorder? *

What is the gender of people who have Connective tissue disorder when taking Tramadol? *

female: 93.62 %
male: 6.38 %

What is the age of people who have Connective tissue disorder when taking Tramadol? *

What are other drugs people take besides Tramadol? *

What are other side effects people have besides Connective tissue disorder? *

Balance Disorder: 21 people, 43.75%
Fall: 20 people, 41.67%
Musculoskeletal Disorder (disease of the body's muscles, joints, tendons, ligaments and nerves): 20 people, 41.67%
Nausea (feeling of having an urge to vomit): 20 people, 41.67%
Muscle Aches (muscle pain): 16 people, 33.33%
Autoimmune Disorder (a condition in which the immune system attacks the body's normal substances and tissue): 16 people, 33.33%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 15 people, 31.25%
Drug Ineffective: 13 people, 27.08%
Limb Injury: 13 people, 27.08%
Spinal Fracture (fracture in one of vertebrae): 13 people, 27.08%

What are the existing conditions these people have? *

Arrhythmias (irregular heartbeat): 12 people, 25.00%
Age-Related Macular Degeneration: 11 people, 22.92%
Breast Cancer Metastatic: 10 people, 20.83%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 18.75%
Hepatitis C: 9 people, 18.75%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 18.75%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 16.67%
High Blood Pressure: 7 people, 14.58%
Birth Control: 6 people, 12.50%
Stress And Anxiety: 6 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Tramadol and have Connective tissue disorder?

- Check whether Connective tissue disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tramadol:

Tramadol (235,800 reports)

Browse all side effects of Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Connective tissue disorder:

Connective tissue disorder (280 drugs)

Browse all the conditions that are associated with Connective tissue disorder:

Connective tissue disorder (389 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Tramadol) and Tramadol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.