Tramadol and Difficulty in walking - a phase IV clinical study of FDA data

Summary:

Difficulty in walking is reported as a side effect among people who take Tramadol (tramadol hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Omeprazole, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Difficulty in walking when taking Tramadol. It is created by eHealthMe based on reports of 229,782 people who have side effects when taking Tramadol from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Difficulty in walking?

Difficulty in walking is found to be associated with 729 drugs and 978 conditions by eHealthMe. Check the latest studies of Difficulty in walking.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

229,782 people reported to have side effects when taking Tramadol.
Among them, 40 people (0.02%) have Difficulty in walking.

Could Tramadol cause Difficulty in walking?

Among these 40 people:

How long have people been on Tramadol when they have Difficulty in walking? *

What is the gender of people who have Difficulty in walking when taking Tramadol? *

female: 64.1 %
male: 35.9 %

What is the age of people who have Difficulty in walking when taking Tramadol? *

What are other drugs people take besides Tramadol? *

What are other side effects people have besides Difficulty in walking? *

Weakness: 13 people, 32.50%
Joint Pain: 9 people, 22.50%
Fatigue (feeling of tiredness): 6 people, 15.00%
Nausea (feeling of having an urge to vomit): 5 people, 12.50%
Hypoaesthesia (reduced sense of touch or sensation): 5 people, 12.50%
Fall: 5 people, 12.50%
Pain In Extremity: 5 people, 12.50%
Feeling Abnormal: 5 people, 12.50%
Joint Swelling: 4 people, 10.00%
Fluid Retention (an abnormal accumulation of fluid in the blood): 4 people, 10.00%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 10.00%
Osteoporosis (bones weak and more likely to break): 2 people, 5.00%
Neuralgia (pain in one or more nerves): 2 people, 5.00%
High Blood Cholesterol: 2 people, 5.00%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 2 people, 5.00%
Spinal Osteoarthritis (joint cartilage loss in spine): 1 person, 2.50%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 1 person, 2.50%
Radiculitis (inflammation of the spinal nerve roots): 1 person, 2.50%
Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 1 person, 2.50%
Peripheral Neuropathy (damage to nerves of the peripheral nervous system): 1 person, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Tramadol and have Difficulty in walking?

- Check whether Difficulty in walking is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tramadol:

Tramadol (235,800 reports)

Browse all side effects of Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Difficulty in walking:

Difficulty in walking (729 drugs)

Browse all the conditions that are associated with Difficulty in walking:

Difficulty in walking (978 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Tramadol) and Tramadol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.