Tramadol and Haemolysis - a phase IV clinical study of FDA data

Summary:

Haemolysis is reported as a side effect among people who take Tramadol (tramadol hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Furosemide, and have Paroxysmal nocturnal haemoglobinuria.

The phase IV clinical study analyzes which people have Haemolysis when taking Tramadol. It is created by eHealthMe based on reports of 229,782 people who have side effects when taking Tramadol from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Haemolysis?

Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid) is found to be associated with 609 drugs and 838 conditions by eHealthMe. Check the latest studies of Haemolysis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

229,782 people reported to have side effects when taking Tramadol.
Among them, 52 people (0.02%) have Haemolysis.

Among these 52 people:

How long have people been on Tramadol when they have Haemolysis? *

What is the gender of people who have Haemolysis when taking Tramadol? *

female: 40 %
male: 60 %

What is the age of people who have Haemolysis when taking Tramadol? *

What are other drugs people take besides Tramadol? *

What are other side effects people have besides Haemolysis? *

Fever: 15 people, 28.85%
Dyspnea (difficult or laboured breathing): 13 people, 25.00%
Headache (pain in head): 12 people, 23.08%
Weakness: 11 people, 21.15%
Malaise (a feeling of general discomfort or uneasiness): 10 people, 19.23%
Pneumonia: 9 people, 17.31%
Fatigue (feeling of tiredness): 8 people, 15.38%
Blood Lactate Dehydrogenase Increased: 8 people, 15.38%
Anaemia (lack of blood): 8 people, 15.38%
Chest Pain: 7 people, 13.46%

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 9 people, 17.31%
Stress And Anxiety: 6 people, 11.54%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 9.62%
High Blood Pressure: 4 people, 7.69%
Renal Cancer Metastatic (cancer of kidney spreads to other part): 3 people, 5.77%
Constipation: 3 people, 5.77%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 2 people, 3.85%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 2 people, 3.85%
Gastritis (inflammation of stomach): 2 people, 3.85%
Dyspnea (difficult or laboured breathing): 2 people, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Tramadol and have Haemolysis?

- Check whether Haemolysis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tramadol:

Tramadol (235,800 reports)

Haemolysis treatments and more:

Haemolysis (9,155 reports)

Browse all side effects of Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Haemolysis:

Haemolysis (609 drugs)

Browse all the conditions that are associated with Haemolysis:

Haemolysis (838 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Tramadol) and Tramadol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.