Tramadol and Hypercoagulation - a phase IV clinical study of FDA data

Summary:

Hypercoagulation is reported as a side effect among people who take Tramadol (tramadol hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Flexeril, and have Metastases to bone.

The phase IV clinical study analyzes which people have Hypercoagulation when taking Tramadol. It is created by eHealthMe based on reports of 229,782 people who have side effects when taking Tramadol from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.

What is Hypercoagulation?

Hypercoagulation (increased tendency for clotting of the blood) is found to be associated with 385 drugs and 537 conditions by eHealthMe. Check the latest studies of Hypercoagulation.

On Jul, 06, 2026

229,782 people reported to have side effects when taking Tramadol.
Among them, 52 people (0.02%) have Hypercoagulation.

Among these 52 people:

How long have people been on Tramadol when they have Hypercoagulation? *

What is the gender of people who have Hypercoagulation when taking Tramadol? *

female: 70.83 %
male: 29.17 %

What is the age of people who have Hypercoagulation when taking Tramadol? *

What are other drugs people take besides Tramadol? *

What are other side effects people have besides Hypercoagulation? *

Fatigue (feeling of tiredness): 26 people, 50.00%
Fall: 26 people, 50.00%
Dyspnea (difficult or laboured breathing): 25 people, 48.08%
Anaemia (lack of blood): 24 people, 46.15%
Joint Pain: 24 people, 46.15%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 23 people, 44.23%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 23 people, 44.23%
Swelling: 23 people, 44.23%
Weight Decreased: 21 people, 40.38%
Arthropathy: 21 people, 40.38%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 20 people, 38.46%
High Blood Cholesterol: 6 people, 11.54%
Type 2 Diabetes: 5 people, 9.62%
Nausea (feeling of having an urge to vomit): 5 people, 9.62%
Thrombosis (formation of a blood clot inside a blood vessel): 4 people, 7.69%
Nausea And Vomiting: 4 people, 7.69%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 4 people, 7.69%
Primary Myelofibrosis (primary disorder of the bone marrow): 4 people, 7.69%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 5.77%
Diabetes: 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

Do you take Tramadol and have Hypercoagulation?

- Check whether Hypercoagulation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tramadol:

Tramadol (235,798 reports)

Browse all side effects of Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercoagulation:

Hypercoagulation (385 drugs)

Browse all the conditions that are associated with Hypercoagulation:

Hypercoagulation (537 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Tramadol) and Tramadol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.