Tramadol and Meniscal degeneration - a phase IV clinical study of FDA data

Summary:

Meniscal degeneration is reported as a side effect among people who take Tramadol (tramadol hydrochloride), especially for people who are male, 60+ old, also take Doxycycline, and have Muscle spasms.

The phase IV clinical study analyzes which people have Meniscal degeneration when taking Tramadol. It is created by eHealthMe based on reports of 229,782 people who have side effects when taking Tramadol from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Meniscal degeneration?

Meniscal degeneration (loss of function in a crescent-shaped piece of cartilage between the femur and the tibia) is found to be associated with 67 drugs and 86 conditions by eHealthMe. Check the latest studies of Meniscal degeneration.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

229,782 people reported to have side effects when taking Tramadol.
Among them, 17 people (0.01%) have Meniscal degeneration.

Could Tramadol cause Meniscal degeneration?

Among these 17 people:

What is the gender of people who have Meniscal degeneration when taking Tramadol? *

female: 35.29 %
male: 64.71 %

What is the age of people who have Meniscal degeneration when taking Tramadol? *

What are other drugs people take besides Tramadol? *

What are other side effects people have besides Meniscal degeneration? *

Weakness: 13 people, 76.47%
Spinal Column Stenosis (narrowing of spinal column): 12 people, 70.59%
Jaw Fracture: 12 people, 70.59%
Joint Effusion (presence of extra fluid in joint covering): 12 people, 70.59%
Lumbar Spinal Stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone): 12 people, 70.59%
Fall: 12 people, 70.59%
Enlarged Heart: 12 people, 70.59%
Dyspnea (difficult or laboured breathing): 12 people, 70.59%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 12 people, 70.59%
Cataract (clouding of the lens inside the eye): 12 people, 70.59%

What are the existing conditions these people have? *

Toothaches (tooth pain): 11 people, 64.71%
Muscle Spasms (muscle contraction): 11 people, 64.71%
Depression: 5 people, 29.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 23.53%
Hypersensitivity: 3 people, 17.65%
Bone Neoplasm Malignant (cancer of bone): 3 people, 17.65%
Cardiac Disorder: 3 people, 17.65%
High Blood Pressure: 3 people, 17.65%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 17.65%
Joint Pain: 3 people, 17.65%

* Approximation only. Some reports may have incomplete information.

Do you take Tramadol and have Meniscal degeneration?

- Check whether Meniscal degeneration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tramadol:

Tramadol (235,800 reports)

Browse all side effects of Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Meniscal degeneration:

Meniscal degeneration (67 drugs)

Browse all the conditions that are associated with Meniscal degeneration:

Meniscal degeneration (86 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Tramadol) and Tramadol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.