Tramadol and Perforated ulcer - a phase IV clinical study of FDA data

Summary:

Perforated ulcer is reported as a side effect among people who take Tramadol (tramadol hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Valium, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Perforated ulcer when taking Tramadol. It is created by eHealthMe based on reports of 229,782 people who have side effects when taking Tramadol from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.

What is Perforated ulcer?

Perforated ulcer is found to be associated with 118 drugs and 266 conditions by eHealthMe. Check the latest studies of Perforated ulcer.

On Jul, 14, 2026

229,782 people reported to have side effects when taking Tramadol.
Among them, 15 people (0.01%) have Perforated ulcer.

Among these 15 people:

How long have people been on Tramadol when they have Perforated ulcer? *

What is the gender of people who have Perforated ulcer when taking Tramadol? *

female: 73.33 %
male: 26.67 %

What is the age of people who have Perforated ulcer when taking Tramadol? *

What are other drugs people take besides Tramadol? *

Prilosec: 3 people, 20.00%
Elavil: 3 people, 20.00%
Atarax: 3 people, 20.00%
Gilenya: 3 people, 20.00%
Valium: 3 people, 20.00%
Cellcept: 2 people, 13.33%
Humira: 2 people, 13.33%
Ibandronate Sodium: 1 person, 6.67%
Hydrocodone Bitartrate And Acetaminophen: 1 person, 6.67%
Insulin: 1 person, 6.67%

What are other side effects people have besides Perforated ulcer? *

Hypoglycemia (low blood sugar): 3 people, 20.00%
Weight Decreased: 3 people, 20.00%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 2 people, 13.33%
Mobility Decreased (ability to move is reduced): 2 people, 13.33%
Nausea And Vomiting: 2 people, 13.33%
Disseminated Tuberculosis: 2 people, 13.33%
Diarrhea: 2 people, 13.33%
Constipation: 2 people, 13.33%
Gastric Ulcer (stomach ulcer): 2 people, 13.33%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 13.33%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 26.67%
Insomnia (sleeplessness): 2 people, 13.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 13.33%
Neuralgia (pain in one or more nerves): 2 people, 13.33%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 13.33%
Hyperglycemia (high blood sugar): 1 person, 6.67%
Arrhythmias (irregular heartbeat): 1 person, 6.67%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 6.67%
Bone Pain: 1 person, 6.67%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Tramadol and have Perforated ulcer?

- Check whether Perforated ulcer is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tramadol:

Tramadol (235,798 reports)

Browse all side effects of Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Perforated ulcer:

Perforated ulcer (118 drugs)

Browse all the conditions that are associated with Perforated ulcer:

Perforated ulcer (266 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Tramadol) and Tramadol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.