Tranxene and Interstitial nephritis - a phase IV clinical study of FDA data

Summary:

Interstitial nephritis is reported as a side effect among people who take Tranxene (clorazepate dipotassium), especially for people who are female, 50-59 old, have been taking the drug for 10+ years also take Oxycontin, and have Bronchial carcinoma.

The phase IV clinical study analyzes which people have Interstitial nephritis when taking Tranxene. It is created by eHealthMe based on reports of 6,399 people who have side effects when taking Tranxene from the FDA, and is updated regularly.

What is Tranxene?

Tranxene has active ingredients of clorazepate dipotassium. It is often used in stress and anxiety. eHealthMe is studying from 6,550 Tranxene users. Check the latest studies of Tranxene.

What is Interstitial nephritis?

Interstitial nephritis (inflammation of the kidney) is found to be associated with 1,085 drugs and 1,568 conditions by eHealthMe. Check the latest studies of Interstitial nephritis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

6,399 people reported to have side effects when taking Tranxene.
Among them, 18 people (0.28%) have Interstitial nephritis.

Could Tranxene cause Interstitial nephritis?

Among these 18 people:

How long have people been on Tranxene when they have Interstitial nephritis? *

What is the gender of people who have Interstitial nephritis when taking Tranxene? *

female: 64.71 %
male: 35.29 %

What is the age of people who have Interstitial nephritis when taking Tranxene? *

What are other drugs people take besides Tranxene? *

Zopiclone: 7 people, 38.89%
Pemetrexed: 7 people, 38.89%
Amlodipine: 7 people, 38.89%
Folic Acid: 7 people, 38.89%
Oxycodone Hydrochloride: 7 people, 38.89%
Oxycontin: 7 people, 38.89%
Doxepin Hydrochloride: 6 people, 33.33%
Keytruda: 6 people, 33.33%
Nexium: 6 people, 33.33%
Premarin: 5 people, 27.78%

What are other side effects people have besides Interstitial nephritis? *

Hypophysitis (inflammation of the pituitary gland): 7 people, 38.89%
Encephalitis (inflammation of the brain): 7 people, 38.89%
Acute Kidney Failure: 5 people, 27.78%
Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 22.22%
Chronic Kidney Disease: 4 people, 22.22%
Cystitis Interstitial (unknown cause characterized by bladder pain): 4 people, 22.22%
Dementia (madness): 4 people, 22.22%
Acute Coronary Syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 4 people, 22.22%
Renal Cyst (kidney cyst): 4 people, 22.22%
Nephropathy (damage to or disease of a kidney): 3 people, 16.67%

What are the existing conditions these people have? *

Bronchial Carcinoma (lung cancer): 7 people, 38.89%
High Blood Pressure: 6 people, 33.33%
Ulcer Haemorrhage (bleeding ulcer): 4 people, 22.22%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 4 people, 22.22%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 22.22%
Depression: 4 people, 22.22%
Urinary Tract Infection Enterococcal: 2 people, 11.11%
Muscle Contracture (a permanent shortening of a muscle): 2 people, 11.11%
Hiv Infection: 2 people, 11.11%
Gastric Ulcer (stomach ulcer): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Tranxene and have Interstitial nephritis?

- Check whether Interstitial nephritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tranxene:

Tranxene (6,550 reports)

Browse all side effects of Tranxene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Interstitial nephritis:

Interstitial nephritis (1,085 drugs)

Browse all the conditions that are associated with Interstitial nephritis:

Interstitial nephritis (1,568 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on clorazepate dipotassium (the active ingredients of Tranxene) and Tranxene (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.