Trazodone hydrochloride and Clostridium difficile colitis - a phase IV clinical study of FDA data

Summary:

Clostridium difficile colitis is reported as a side effect among people who take Trazodone hydrochloride (trazodone hydrochloride), especially for people who are male, 60+ old, also take Pantoprazole, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Clostridium difficile colitis when taking Trazodone hydrochloride. It is created by eHealthMe based on reports of 17,393 people who have side effects when taking Trazodone hydrochloride from the FDA, and is updated regularly.

What is Trazodone hydrochloride?

Trazodone hydrochloride has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 23,016 Trazodone hydrochloride users. Check the latest studies of Trazodone hydrochloride.

What is Clostridium difficile colitis?

Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection) is found to be associated with 1,040 drugs and 1,786 conditions by eHealthMe. Check the latest studies of Clostridium difficile colitis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

17,393 people reported to have side effects when taking Trazodone hydrochloride.
Among them, 14 people (0.08%) have Clostridium difficile colitis.

Could Trazodone hydrochloride cause Clostridium difficile colitis?

Among these 14 people:

What is the gender of people who have Clostridium difficile colitis when taking Trazodone hydrochloride? *

female: 28.57 %
male: 71.43 %

What is the age of people who have Clostridium difficile colitis when taking Trazodone hydrochloride? *

What are other drugs people take besides Trazodone hydrochloride? *

What are other side effects people have besides Clostridium difficile colitis? *

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 6 people, 42.86%
Fatigue (feeling of tiredness): 6 people, 42.86%
Dyspnea (difficult or laboured breathing): 6 people, 42.86%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 4 people, 28.57%
Febrile Neutropenia (fever with reduced white blood cells): 4 people, 28.57%
Abdominal Pain: 4 people, 28.57%
Chest Pain: 4 people, 28.57%
Headache (pain in head): 4 people, 28.57%
Nausea (feeling of having an urge to vomit): 4 people, 28.57%
Diarrhea: 4 people, 28.57%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 5 people, 35.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 28.57%
Nausea (feeling of having an urge to vomit): 4 people, 28.57%
Tumor Lysis Syndrome: 3 people, 21.43%
Pain: 3 people, 21.43%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 21.43%
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking): 3 people, 21.43%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 3 people, 21.43%
Stress And Anxiety: 2 people, 14.29%
Eye Infection: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Trazodone hydrochloride and have Clostridium difficile colitis?

- Check whether Clostridium difficile colitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Trazodone hydrochloride:

Trazodone hydrochloride (23,016 reports)

Browse all side effects of Trazodone hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Clostridium difficile colitis:

Clostridium difficile colitis (1,040 drugs)

Browse all the conditions that are associated with Clostridium difficile colitis:

Clostridium difficile colitis (1,786 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on trazodone hydrochloride (the active ingredients of Trazodone hydrochloride) and Trazodone hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.