Trexall and Herpes zoster - a phase IV clinical study of FDA data

Summary:

Herpes zoster is reported as a side effect among people who take Trexall (methotrexate sodium), especially for people who are female, 50-59 old, also take Enbrel, and have Crohn's disease.

The phase IV clinical study analyzes which people have Herpes zoster when taking Trexall. It is created by eHealthMe based on reports of 1,394 people who have side effects when taking Trexall from the FDA, and is updated regularly.

What is Trexall?

Trexall has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 1,439 Trexall users. Check the latest studies of Trexall.

What is Herpes zoster?

Herpes zoster is found to be associated with 1,819 drugs and 2,172 conditions by eHealthMe. Check the latest studies of Herpes zoster.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

1,394 people reported to have side effects when taking Trexall.
Among them, 20 people (1.43%) have Herpes zoster.

Among these 20 people:

What is the gender of people who have Herpes zoster when taking Trexall? *

female: 75 %
male: 25 %

What is the age of people who have Herpes zoster when taking Trexall? *

What are other drugs people take besides Trexall? *

What are other side effects people have besides Herpes zoster? *

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 3 people, 15.00%
Hypoaesthesia (reduced sense of touch or sensation): 2 people, 10.00%
Pain: 2 people, 10.00%
Sinusitis (inflammation of sinus): 2 people, 10.00%
High Blood Pressure: 2 people, 10.00%
Fever: 2 people, 10.00%
Fatigue (feeling of tiredness): 2 people, 10.00%
Vascular Insufficiency: 1 person, 5.00%
Eye Infection: 1 person, 5.00%
Influenza Like Illness: 1 person, 5.00%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 15.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Trexall and have Herpes zoster?

- Check whether Herpes zoster is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Trexall:

Trexall (1,439 reports)

Herpes zoster treatments and more:

Herpes zoster (88,627 reports)

Browse all side effects of Trexall:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Herpes zoster:

Herpes zoster (1,819 drugs)

Browse all the conditions that are associated with Herpes zoster:

Herpes zoster (2,172 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Trexall) and Trexall (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.