Treximet and Hot flush - a phase IV clinical study of FDA data

Summary:

Hot flush is reported as a side effect among people who take Treximet (naproxen sodium; sumatriptan succinate), especially for people who are 50-59 old, also take Topamax, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Hot flush when taking Treximet. It is created by eHealthMe based on reports of 1,656 people who have side effects when taking Treximet from the FDA, and is updated regularly.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

What is Hot flush?

Hot flush (sudden feelings of heat) is found to be associated with 1,770 drugs and 2,343 conditions by eHealthMe. Check the latest studies of Hot flush.

On Jul, 21, 2026

1,656 people reported to have side effects when taking Treximet.
Among them, 15 people (0.91%) have Hot flush.

Among these 15 people:

What is the age of people who have Hot flush when taking Treximet? *

What are other drugs people take besides Treximet? *

What are other side effects people have besides Hot flush? *

Tremor (trembling or shaking movements in one or more parts of your body): 5 people, 33.33%
Dyspnea (difficult or laboured breathing): 5 people, 33.33%
Nausea (feeling of having an urge to vomit): 4 people, 26.67%
Dizziness: 4 people, 26.67%
Hemiparesis (weakness on one side of the body): 3 people, 20.00%
Hypokalemia (low potassium): 3 people, 20.00%
Malaise (a feeling of general discomfort or uneasiness): 3 people, 20.00%
Headache (pain in head): 3 people, 20.00%
Skin Blushing/flushing (a sudden reddening of the face, neck): 3 people, 20.00%
Chest Pain: 3 people, 20.00%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 33.33%
Headache (pain in head): 3 people, 20.00%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 20.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 20.00%
Menopause (end of monthly cycles in women): 3 people, 20.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 20.00%
Sleep Disorder: 3 people, 20.00%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 20.00%
High Blood Pressure: 3 people, 20.00%
Rickets (softening of bones): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Treximet and have Hot flush?

- Check whether Hot flush is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Treximet:

Treximet (1,904 reports)

Hot flush treatments and more:

Hot flush (91,208 reports)

How severe was Hot flush and when was it recovered:

Hot flush in Treximet

Expand to all the drugs that have ingredients of naproxen sodium; sumatriptan succinate:

Hot flush and drugs with ingredients of naproxen sodium; sumatriptan succinate (307 reports)

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Treximet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hot flush:

Hot flush (1,770 drugs)

Browse all the conditions that are associated with Hot flush:

Hot flush (2,343 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium; sumatriptan succinate (the active ingredients of Treximet) and Treximet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.