Treximet and Pain - a phase IV clinical study of FDA data

Summary:

Pain is reported as a side effect among people who take Treximet (naproxen sodium; sumatriptan succinate), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Yaz, and have Premenstrual syndrome.

The phase IV clinical study analyzes which people have Pain when taking Treximet. It is created by eHealthMe based on reports of 1,656 people who have side effects when taking Treximet from the FDA, and is updated regularly.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

What is Pain?

Pain is found to be associated with 3,813 drugs and 5,869 conditions by eHealthMe. Check the latest studies of Pain.

On Jul, 27, 2026

1,656 people reported to have side effects when taking Treximet.
Among them, 96 people (5.8%) have Pain.

Among these 96 people:

How long have people been on Treximet when they have Pain? *

What is the gender of people who have Pain when taking Treximet? *

female: 93.41 %
male: 6.59 %

What is the age of people who have Pain when taking Treximet? *

What are other drugs people take besides Treximet? *

Yasmin: 20 people, 20.83%
Yaz: 20 people, 20.83%
Xanax: 14 people, 14.58%
Imitrex: 13 people, 13.54%
Topamax: 12 people, 12.50%
Lyrica: 9 people, 9.38%
Drospirenone And Ethinyl Estradiol: 8 people, 8.33%
Bentyl: 8 people, 8.33%
Motrin: 8 people, 8.33%
Nexium: 8 people, 8.33%

What are other side effects people have besides Pain? *

Injury: 33 people, 34.38%
Stress And Anxiety: 28 people, 29.17%
Headache (pain in head): 19 people, 19.79%
Emotional Distress: 15 people, 15.62%
Fatigue (feeling of tiredness): 14 people, 14.58%
Gallstones (stone formation by bile component): 13 people, 13.54%
Gallbladder Disorder: 12 people, 12.50%
Pulmonary Embolism (blockage of the main artery of the lung): 12 people, 12.50%
Nausea (feeling of having an urge to vomit): 11 people, 11.46%
Abdominal Pain: 10 people, 10.42%

What are the existing conditions these people have? *

Premenstrual Syndrome: 15 people, 15.62%
Acne (skin problems that cause pimples): 9 people, 9.38%
Birth Control: 9 people, 9.38%
Headache (pain in head): 9 people, 9.38%
Insomnia (sleeplessness): 5 people, 5.21%
Nausea (feeling of having an urge to vomit): 5 people, 5.21%
Stress And Anxiety: 5 people, 5.21%
Muscle Spasms (muscle contraction): 5 people, 5.21%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.21%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 4 people, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Treximet and have Pain?

- Check whether Pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Treximet:

Treximet (1,904 reports)

Pain treatments and more:

Pain (1,140,594 reports)

How severe was Pain and when was it recovered:

Pain in Treximet

Expand to all the drugs that have ingredients of naproxen sodium; sumatriptan succinate:

Pain and drugs with ingredients of naproxen sodium; sumatriptan succinate (4,573 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Treximet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pain:

Pain (3,813 drugs)

Browse all the conditions that are associated with Pain:

Pain (5,869 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium; sumatriptan succinate (the active ingredients of Treximet) and Treximet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.