Tri-sprintec and Cough aggravated - a phase IV clinical study of FDA data

Summary:

Cough aggravated is reported as a side effect among people who take Tri-sprintec (ethinyl estradiol; norgestimate), especially for people who are female, 30-39 old, have been taking the drug for 10+ years also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Cough aggravated when taking Tri-sprintec. It is created by eHealthMe based on reports of 1,038 people who have side effects when taking Tri-sprintec from the FDA, and is updated regularly.

What is Tri-sprintec?

Tri-sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 1,428 Tri-sprintec users. Check the latest studies of Tri-sprintec.

What is Cough aggravated?

Cough aggravated is found to be associated with 2,463 drugs and 905 conditions by eHealthMe. Check the latest studies of Cough aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

1,038 people reported to have side effects when taking Tri-sprintec.
Among them, 16 people (1.54%) have Cough aggravated.

Could Tri-sprintec cause Cough aggravated?

Among these 16 people:

How long have people been on Tri-sprintec when they have Cough aggravated? *

What is the gender of people who have Cough aggravated when taking Tri-sprintec? *

female: 100 %
male: 0.0 %

What is the age of people who have Cough aggravated when taking Tri-sprintec? *

What are other drugs people take besides Tri-sprintec? *

What are other side effects people have besides Cough aggravated? *

Dyspnea (difficult or laboured breathing): 5 people, 31.25%
High Blood Pressure: 4 people, 25.00%
Oropharyngeal Pain: 3 people, 18.75%
Pneumonia: 3 people, 18.75%
Fatigue (feeling of tiredness): 3 people, 18.75%
Headache (pain in head): 2 people, 12.50%
Gastric Ulcer (stomach ulcer): 2 people, 12.50%
Lipoma (a growth of fatty tissue that slowly develops just under your skin): 2 people, 12.50%
Fever: 2 people, 12.50%
Migraine (headache): 2 people, 12.50%

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 25.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 25.00%
Weight Decreased: 2 people, 12.50%
Panic Disorder: 2 people, 12.50%
Alcoholism (problems with alcohol): 2 people, 12.50%
Drug Dependence: 2 people, 12.50%
Migraine (headache): 2 people, 12.50%
High Blood Cholesterol: 2 people, 12.50%
Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places): 2 people, 12.50%
Cystitis Interstitial (unknown cause characterized by bladder pain): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Tri-sprintec and have Cough aggravated?

- Check whether Cough aggravated is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tri-sprintec:

Tri-sprintec (1,428 reports)

Cough aggravated treatments and more:

Cough aggravated (281 reports)

How severe was Cough aggravated and when was it recovered:

Cough aggravated in Tri-sprintec

Expand to all the drugs that have ingredients of ethinyl estradiol; norgestimate:

Cough aggravated and drugs with ingredients of ethinyl estradiol; norgestimate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tri-sprintec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cough aggravated:

Cough aggravated (2,463 drugs)

Browse all the conditions that are associated with Cough aggravated:

Cough aggravated (905 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norgestimate (the active ingredients of Tri-sprintec) and Tri-sprintec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.