Trihexyphenidyl hydrochloride and Muscle rigidity - a phase IV clinical study of FDA data

Summary:

Muscle rigidity is reported as a side effect among people who take Trihexyphenidyl hydrochloride (trihexyphenidyl hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Olanzapine, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Muscle rigidity when taking Trihexyphenidyl hydrochloride. It is created by eHealthMe based on reports of 1,053 people who have side effects when taking Trihexyphenidyl hydrochloride from the FDA, and is updated regularly.

What is Trihexyphenidyl hydrochloride?

Trihexyphenidyl hydrochloride has active ingredients of trihexyphenidyl hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 1,118 Trihexyphenidyl hydrochloride users. Check the latest studies of Trihexyphenidyl hydrochloride.

What is Muscle rigidity?

Muscle rigidity (muscle stiffness) is found to be associated with 787 drugs and 1,035 conditions by eHealthMe. Check the latest studies of Muscle rigidity.

On Jul, 12, 2026

1,053 people reported to have side effects when taking Trihexyphenidyl hydrochloride.
Among them, 17 people (1.61%) have Muscle rigidity.

Could Trihexyphenidyl hydrochloride cause Muscle rigidity?

Among these 17 people:

How long have people been on Trihexyphenidyl hydrochloride when they have Muscle rigidity? *

What is the gender of people who have Muscle rigidity when taking Trihexyphenidyl hydrochloride? *

female: 52.94 %
male: 47.06 %

What is the age of people who have Muscle rigidity when taking Trihexyphenidyl hydrochloride? *

What are other drugs people take besides Trihexyphenidyl hydrochloride? *

What are other side effects people have besides Muscle rigidity? *

Agitation (state of anxiety or nervous excitement): 5 people, 29.41%
Stress And Anxiety: 5 people, 29.41%
Depression: 4 people, 23.53%
Delusion (a false belief or opinion): 4 people, 23.53%
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases): 4 people, 23.53%
Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 4 people, 23.53%
Tremor (trembling or shaking movements in one or more parts of your body): 4 people, 23.53%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 4 people, 23.53%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 17.65%
Depressed Level Of Consciousness: 3 people, 17.65%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 11.76%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 11.76%
Depression: 2 people, 11.76%
Bipolar Disorder (mood disorder): 2 people, 11.76%
Mania (a state of abnormally elevated or irritable mood): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Trihexyphenidyl hydrochloride and have Muscle rigidity?

- Check whether Muscle rigidity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Trihexyphenidyl hydrochloride:

Trihexyphenidyl hydrochloride (1,118 reports)

Muscle rigidity treatments and more:

Muscle rigidity (16,888 reports)

Browse all side effects of Trihexyphenidyl hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rigidity:

Muscle rigidity (787 drugs)

Browse all the conditions that are associated with Muscle rigidity:

Muscle rigidity (1,035 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on trihexyphenidyl hydrochloride (the active ingredients of Trihexyphenidyl hydrochloride) and Trihexyphenidyl hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.